Dinuclear Tetrapyrazolyl Palladium Complexes Exhibiting Facile Tandem Transfer Hydrogenation/Suzuki Coupling Reaction of Fluoroarylketone

Niranjan Dehury, Niladri Maity, Suman Kumar Tripathy, Jean-Marie Basset, Srikanta Patra

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27 Scopus citations


Herein, we report an unprecedented example of dinuclear pyrazolyl-based Pd complexes exhibiting facile tandem catalysis for fluoroarylketone: Tetrapyrazolyl di-palladium complexes with varying Pd-Pd distances efficiently catalyze the tandem reaction involving transfer hydrogenation of fluoroarylketone to the corresponding alcohol and Suzuki-Miyaura cross coupling reaction of the resulting fluoroarylalcohol under moderate reaction conditions, to biaryl alcohol. The complex with the shortest Pd-Pd distance exhibits the highest tandem activity among its di-metallic analogues, and exceeds in terms of activity and selectivity the analogous mononuclear compound. The kinetics of the reaction indicates clearly that reductive transformation of haloarylketone into haloaryalcohol is the rate determining step in the tandem reaction. Interestingly while fluoroarylketone undergoes the multistep tandem catalysis, the chloro- and bromo-arylketones undergo only a single step C-C coupling reaction resulting in biarylketone as the final product. Unlike the pyrazole based Pd compounds, the precursor PdCl2 and the phosphine based relevant complexes (PPh3)2PdCl2 and (PPh3)4Pd are found to be unable to exhibit the tandem catalysis.
Original languageEnglish (US)
Pages (from-to)5535-5540
Number of pages6
JournalACS Catalysis
Issue number8
StatePublished - Jul 26 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work has been supported by DST (EMR/2015/002219), New
Delhi, India. ND and SKT are grateful to the University Grant
Commission (UGC) and the Council of Scientific and Industrial
Research (CSIR), New Delhi, India, respectively, for their fellowship.
N. M. acknowledges the King Abdullah University of Science
and Technology (KAUST) for the postdoctoral fellowship.
The authors are grateful to the reviewers’ for their valuable comments
and suggestions to improve the manuscript.


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