Abstract
The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 884-886 |
| Number of pages | 3 |
| Journal | Journal of Hepatology |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
Bibliographical note
Funding Information:of Japan. JYNL was supported in part by the DSR-D-I 5, DSR-RDA-I-15 grants from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; the American Liver Association Hans Popper Liver Scholar Award; and the Glaxo Institute of Digestive Health Clinical Investigator Award.
Funding Information:
MM was supported by grants from the Japanese Ministry of Welfare and Viral Hepatitis Research Foundation
Keywords
- Hepatitis C virus
- Interferon-α
- Molecular evolutionary analysis
- Quasispecies
- Selection
ASJC Scopus subject areas
- Hepatology
