Differential expression of Tbx4 and Tbx5 in Zebrafish Fin buds

Koji Tamura; Sayuri Yonei-Tamura; Juan Carlos Izpisúa Belmonte

doi:10.1016/S0925-4773(99)00126-4

Differential expression of Tbx4 and Tbx5 in Zebrafish Fin buds

Koji Tamura, Sayuri Yonei-Tamura, Juan Carlos Izpisúa Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	181-184
Number of pages	4
Journal	Mechanisms of Development
Volume	87
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(99)00126-4
State	Published - Sep 1 1999
Externally published	Yes

Keywords

Embryogenesis
Fin bud
Gene expression
T-box
Tbx4
Tbx5
Zebrafish

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(99)00126-4

Cite this

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title = "Differential expression of Tbx4 and Tbx5 in Zebrafish Fin buds",

abstract = "In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Embryogenesis, Fin bud, Gene expression, T-box, Tbx4, Tbx5, Zebrafish",

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AU - Tamura, Koji

AU - Yonei-Tamura, Sayuri

AU - Belmonte, Juan Carlos Izpisúa

PY - 1999/9/1

Y1 - 1999/9/1

N2 - In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Embryogenesis

KW - Fin bud

KW - Gene expression

KW - T-box

KW - Tbx4

KW - Tbx5

KW - Zebrafish

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Differential expression of Tbx4 and Tbx5 in Zebrafish Fin buds

Abstract

Keywords

ASJC Scopus subject areas

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