Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): Perspectives on vector-borne diseases symbiotic control

Irene Ricci; Michela Mosca; Matteo Valzano; Claudia Damiani; Patrizia Scuppa; Paolo Rossi; Elena Crotti; Alessia Cappelli; Ulisse Ulissi; Aida Capone; Fulvio Esposito; Alberto Alma; Mauro Mandrioli; Luciano Sacchi; Claudio Bandi; Daniele Daffonchio; Guido Favia

doi:10.1007/s10482-010-9532-3

Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): Perspectives on vector-borne diseases symbiotic control

Irene Ricci, Michela Mosca, Matteo Valzano, Claudia Damiani, Patrizia Scuppa, Paolo Rossi, Elena Crotti, Alessia Cappelli, Ulisse Ulissi, Aida Capone, Fulvio Esposito, Alberto Alma, Mauro Mandrioli, Luciano Sacchi, Claudio Bandi, Daniele Daffonchio, Guido Favia^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The genetic manipulation of the microbial community associated with hematophagus insects is particularly relevant for public health applications. Within mosquito populations, this relationship has been overlooked until recently. New advances in molecular biotechnology propose the genetic manipulation of mosquito symbionts to prevent the transmission of pathogens to humans by interfering with the obligatory life cycle stages within the insect through the use of effector molecules. This approach, defined as 'paratransgenesis', has opened the way for the investigation and characterization of microbes residing in the mosquito body, particularly those localised within the gut. Some interesting bacteria have been identified as candidates for genetic modification, however, endosymbiotic yeasts remain largely unexplored with little information on the symbiotic relationships to date. Here we review the recent report of symbiotic relationship between Wickerhamomyces anomalus (Pichia anomala) and several mosquito vector species as promising methods to implement control of mosquito-borne diseases.

Original language	English (US)
Pages (from-to)	43-50
Number of pages	8
Journal	Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology
Volume	99
Issue number	1
DOIs	https://doi.org/10.1007/s10482-010-9532-3
State	Published - Jan 2011
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments I.R. was funded by ‘‘Compagnia di San Paolo’’ in the context of the Italian Malaria Network. E.C. and P.R. received a travel Grant from the COST Action FA0701. The research activity was supported by Firb-Ideas (Grant RBID082MLZ) and Prin 2007 (Grant 2007PK2HB7-002) both from the Italian Ministry of Education, University and Research (MIUR) to G.F.We thank Chenoa De Freece for English revision of the manuscript.

Keywords

Aedes
Anopheles
Endosymbionts
Gonads
Insects
Malaria
Microbial community
Midgut
Mosquito
Paratransgenesis
Pichia anomala
Symbiotic control
Vector-borne diseases
Wickerhamomyces anomalus
Yeast

ASJC Scopus subject areas

Microbiology
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10482-010-9532-3

Cite this

Ricci, I., Mosca, M., Valzano, M., Damiani, C., Scuppa, P., Rossi, P., Crotti, E., Cappelli, A., Ulissi, U., Capone, A., Esposito, F., Alma, A., Mandrioli, M., Sacchi, L., Bandi, C., Daffonchio, D., & Favia, G. (2011). Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): Perspectives on vector-borne diseases symbiotic control. Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, 99(1), 43-50. https://doi.org/10.1007/s10482-010-9532-3

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abstract = "The genetic manipulation of the microbial community associated with hematophagus insects is particularly relevant for public health applications. Within mosquito populations, this relationship has been overlooked until recently. New advances in molecular biotechnology propose the genetic manipulation of mosquito symbionts to prevent the transmission of pathogens to humans by interfering with the obligatory life cycle stages within the insect through the use of effector molecules. This approach, defined as 'paratransgenesis', has opened the way for the investigation and characterization of microbes residing in the mosquito body, particularly those localised within the gut. Some interesting bacteria have been identified as candidates for genetic modification, however, endosymbiotic yeasts remain largely unexplored with little information on the symbiotic relationships to date. Here we review the recent report of symbiotic relationship between Wickerhamomyces anomalus (Pichia anomala) and several mosquito vector species as promising methods to implement control of mosquito-borne diseases.",

keywords = "Aedes, Anopheles, Endosymbionts, Gonads, Insects, Malaria, Microbial community, Midgut, Mosquito, Paratransgenesis, Pichia anomala, Symbiotic control, Vector-borne diseases, Wickerhamomyces anomalus, Yeast",

author = "Irene Ricci and Michela Mosca and Matteo Valzano and Claudia Damiani and Patrizia Scuppa and Paolo Rossi and Elena Crotti and Alessia Cappelli and Ulisse Ulissi and Aida Capone and Fulvio Esposito and Alberto Alma and Mauro Mandrioli and Luciano Sacchi and Claudio Bandi and Daniele Daffonchio and Guido Favia",

note = "Funding Information: Acknowledgments I.R. was funded by {\textquoteleft}{\textquoteleft}Compagnia di San Paolo{\textquoteright}{\textquoteright} in the context of the Italian Malaria Network. E.C. and P.R. received a travel Grant from the COST Action FA0701. The research activity was supported by Firb-Ideas (Grant RBID082MLZ) and Prin 2007 (Grant 2007PK2HB7-002) both from the Italian Ministry of Education, University and Research (MIUR) to G.F.We thank Chenoa De Freece for English revision of the manuscript.",

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Ricci, I, Mosca, M, Valzano, M, Damiani, C, Scuppa, P, Rossi, P, Crotti, E, Cappelli, A, Ulissi, U, Capone, A, Esposito, F, Alma, A, Mandrioli, M, Sacchi, L, Bandi, C, Daffonchio, D & Favia, G 2011, 'Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): Perspectives on vector-borne diseases symbiotic control', Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, vol. 99, no. 1, pp. 43-50. https://doi.org/10.1007/s10482-010-9532-3

Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): Perspectives on vector-borne diseases symbiotic control. / Ricci, Irene; Mosca, Michela; Valzano, Matteo et al.
In: Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, Vol. 99, No. 1, 01.2011, p. 43-50.

Research output: Contribution to journal › Article › peer-review

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T1 - Different mosquito species host Wickerhamomyces anomalus (Pichia anomala)

T2 - Perspectives on vector-borne diseases symbiotic control

AU - Ricci, Irene

AU - Mosca, Michela

AU - Valzano, Matteo

AU - Damiani, Claudia

AU - Scuppa, Patrizia

AU - Rossi, Paolo

AU - Crotti, Elena

AU - Cappelli, Alessia

AU - Ulissi, Ulisse

AU - Capone, Aida

AU - Esposito, Fulvio

AU - Alma, Alberto

AU - Mandrioli, Mauro

AU - Sacchi, Luciano

AU - Bandi, Claudio

AU - Daffonchio, Daniele

AU - Favia, Guido

N1 - Funding Information: Acknowledgments I.R. was funded by ‘‘Compagnia di San Paolo’’ in the context of the Italian Malaria Network. E.C. and P.R. received a travel Grant from the COST Action FA0701. The research activity was supported by Firb-Ideas (Grant RBID082MLZ) and Prin 2007 (Grant 2007PK2HB7-002) both from the Italian Ministry of Education, University and Research (MIUR) to G.F.We thank Chenoa De Freece for English revision of the manuscript.

PY - 2011/1

Y1 - 2011/1

N2 - The genetic manipulation of the microbial community associated with hematophagus insects is particularly relevant for public health applications. Within mosquito populations, this relationship has been overlooked until recently. New advances in molecular biotechnology propose the genetic manipulation of mosquito symbionts to prevent the transmission of pathogens to humans by interfering with the obligatory life cycle stages within the insect through the use of effector molecules. This approach, defined as 'paratransgenesis', has opened the way for the investigation and characterization of microbes residing in the mosquito body, particularly those localised within the gut. Some interesting bacteria have been identified as candidates for genetic modification, however, endosymbiotic yeasts remain largely unexplored with little information on the symbiotic relationships to date. Here we review the recent report of symbiotic relationship between Wickerhamomyces anomalus (Pichia anomala) and several mosquito vector species as promising methods to implement control of mosquito-borne diseases.

AB - The genetic manipulation of the microbial community associated with hematophagus insects is particularly relevant for public health applications. Within mosquito populations, this relationship has been overlooked until recently. New advances in molecular biotechnology propose the genetic manipulation of mosquito symbionts to prevent the transmission of pathogens to humans by interfering with the obligatory life cycle stages within the insect through the use of effector molecules. This approach, defined as 'paratransgenesis', has opened the way for the investigation and characterization of microbes residing in the mosquito body, particularly those localised within the gut. Some interesting bacteria have been identified as candidates for genetic modification, however, endosymbiotic yeasts remain largely unexplored with little information on the symbiotic relationships to date. Here we review the recent report of symbiotic relationship between Wickerhamomyces anomalus (Pichia anomala) and several mosquito vector species as promising methods to implement control of mosquito-borne diseases.

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KW - Anopheles

KW - Endosymbionts

KW - Gonads

KW - Insects

KW - Malaria

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KW - Midgut

KW - Mosquito

KW - Paratransgenesis

KW - Pichia anomala

KW - Symbiotic control

KW - Vector-borne diseases

KW - Wickerhamomyces anomalus

KW - Yeast

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Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): Perspectives on vector-borne diseases symbiotic control

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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