Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis

Rahul Sharma, Tarun Garg, Amit K. Goyal, Goutam Rath

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The present study is designed to explore the localized delivery of fluconazole using mucoadhesive polymeric nanofibers. Drug-loaded polymeric nanofibers were fabricated by the electrospinning method using polyvinyl alcohol (PVA) as the polymeric constituent. The prepared nanofibers were found to be uniform, non-beaded and non-woven, with the diameter of the fibers ranging from 150 to 180 nm. Further drug release studies indicate a sustained release of fluconazole over a period of 6 h. The results of studies on anti-microbial activity indicated that drug-loaded polymeric nanofibers exhibit superior antimicrobial activity against Candida albicans, when compared to the plain drug.
Original languageEnglish (US)
Pages (from-to)524-531
Number of pages8
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume44
Issue number2
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Pharmaceutical Science
  • Medicine (miscellaneous)

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