Development of transmucosal patch using nanofibers

Harleen Grewal; Sanjay R. Dhakate; Amit K. Goyal; Tanmay S. Markandeywar; Basant Malik; Goutam Rath

doi:10.3109/10731199.2011.637924

Development of transmucosal patch using nanofibers

Harleen Grewal, Sanjay R. Dhakate, Amit K. Goyal, Tanmay S. Markandeywar, Basant Malik, Goutam Rath

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy. © 2012 Informa Healthcare USA, Inc.

Original language	English (US)
Pages (from-to)	146-150
Number of pages	5
Journal	Artificial Cells, Blood Substitutes, and Biotechnology
Volume	40
Issue number	1-2
DOIs	https://doi.org/10.3109/10731199.2011.637924
State	Published - Feb 1 2012
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

Biomedical Engineering
Biotechnology

Access to Document

10.3109/10731199.2011.637924

Cite this

@article{57b2a8d9d5d6432cb637b12b2cdcf7bb,

title = "Development of transmucosal patch using nanofibers",

abstract = "In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy. {\textcopyright} 2012 Informa Healthcare USA, Inc.",

author = "Harleen Grewal and Dhakate, {Sanjay R.} and Goyal, {Amit K.} and Markandeywar, {Tanmay S.} and Basant Malik and Goutam Rath",

note = "Generated from Scopus record by KAUST IRTS on 2023-10-12",

year = "2012",

month = feb,

day = "1",

doi = "10.3109/10731199.2011.637924",

language = "English (US)",

volume = "40",

pages = "146--150",

journal = "Artificial Cells, Blood Substitutes, and Biotechnology",

issn = "1073-1199",

publisher = "Informa Healthcare",

number = "1-2",

}

TY - JOUR

T1 - Development of transmucosal patch using nanofibers

AU - Grewal, Harleen

AU - Dhakate, Sanjay R.

AU - Goyal, Amit K.

AU - Markandeywar, Tanmay S.

AU - Malik, Basant

AU - Rath, Goutam

N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12

PY - 2012/2/1

Y1 - 2012/2/1

N2 - In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy. © 2012 Informa Healthcare USA, Inc.

AB - In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy. © 2012 Informa Healthcare USA, Inc.

UR - http://www.tandfonline.com/doi/full/10.3109/10731199.2011.637924

UR - http://www.scopus.com/inward/record.url?scp=84856592906&partnerID=8YFLogxK

U2 - 10.3109/10731199.2011.637924

DO - 10.3109/10731199.2011.637924

M3 - Article

SN - 1073-1199

VL - 40

SP - 146

EP - 150

JO - Artificial Cells, Blood Substitutes, and Biotechnology

JF - Artificial Cells, Blood Substitutes, and Biotechnology

IS - 1-2

ER -

Development of transmucosal patch using nanofibers

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this