Development of the limb neuromuscular system

Kamal Sharma*, Juan Carlos Izpisúa Belmonte

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Appendages, such as wings of a fly or limbs of a vertebrate, are excellent models to study the principles of patterning and morphogenesis. In the adult these structures are used for a variety of behaviors, including locomotion. Although support structures of the adult vertebrate limb are generated within the limb bud, its dynamic elements are derived from the somitic mesoderm and neural tube. Recent studies show that regional patterns set up in the mesenchyme-filled limb bud guide muscle precursors and developing motor axons to their proper location within the limb. Subsequent development of the neuromuscular system is regulated by cell surface interactions between pre-specified muscle fibers and motor axons.

Original languageEnglish (US)
Pages (from-to)204-210
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number2
StatePublished - Apr 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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