Abstract
The objective of this study was to establish an effective therapy system for wound management. The present work describes preparation of metronidazole/serratiopeptidase loaded alginate microspheres by emulsification method. In vitro characterizations like particle size analysis, % yield, % encapsulation, and in vitro release were carried out. Wound healing assessment was determined by physical, histological, and biochemical methods. Wound healing performance of experimental formulations was compared with marketed product in rabbits. Result obtained for alginate microspheres showed good loading efficiency with spherical in shape. Experimentation suggests wound healing is improved by using serratiopeptidase and metronidazole in full thickness wounds in rabbits. © 2011 Informa Healthcare USA, Inc.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 44-50 |
| Number of pages | 7 |
| Journal | Artificial Cells, Blood Substitutes, and Biotechnology |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2011 |
| Externally published | Yes |
Bibliographical note
Generated from Scopus record by KAUST IRTS on 2023-10-12ASJC Scopus subject areas
- Biomedical Engineering
- Biotechnology