Development of serratiopeptidase and metronidazole based alginate microspheres for wound healing

G. Rath, E. S. Johal, Amit K. Goyal

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The objective of this study was to establish an effective therapy system for wound management. The present work describes preparation of metronidazole/serratiopeptidase loaded alginate microspheres by emulsification method. In vitro characterizations like particle size analysis, % yield, % encapsulation, and in vitro release were carried out. Wound healing assessment was determined by physical, histological, and biochemical methods. Wound healing performance of experimental formulations was compared with marketed product in rabbits. Result obtained for alginate microspheres showed good loading efficiency with spherical in shape. Experimentation suggests wound healing is improved by using serratiopeptidase and metronidazole in full thickness wounds in rabbits. © 2011 Informa Healthcare USA, Inc.
Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Volume39
Issue number1
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biotechnology

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