Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems

Leto Aikaterini Tziveleka; Panayiotis Bilalis; Alexandros Chatzipavlidis; Nikos Boukos; George Kordas

doi:10.1002/mabi.201300212

Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems

Leto Aikaterini Tziveleka^*, Panayiotis Bilalis, Alexandros Chatzipavlidis, Nikos Boukos, George Kordas

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Magnetic nanodevices based on poly[(methacrylic acid)-co-(N- isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.

Original language	English (US)
Pages (from-to)	131-141
Number of pages	11
Journal	Macromolecular Bioscience
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/mabi.201300212
State	Published - Jan 2014
Externally published	Yes

Keywords

drug delivery systems
magnetic polymers
nanocontainers
pH response
temperature response

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mabi.201300212

Cite this

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title = "Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems",

abstract = "Magnetic nanodevices based on poly[(methacrylic acid)-co-(N- isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.",

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author = "Tziveleka, {Leto Aikaterini} and Panayiotis Bilalis and Alexandros Chatzipavlidis and Nikos Boukos and George Kordas",

year = "2014",

month = jan,

doi = "10.1002/mabi.201300212",

language = "English (US)",

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pages = "131--141",

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T1 - Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems

AU - Tziveleka, Leto Aikaterini

AU - Bilalis, Panayiotis

AU - Chatzipavlidis, Alexandros

AU - Boukos, Nikos

AU - Kordas, George

PY - 2014/1

Y1 - 2014/1

N2 - Magnetic nanodevices based on poly[(methacrylic acid)-co-(N- isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.

AB - Magnetic nanodevices based on poly[(methacrylic acid)-co-(N- isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.

KW - drug delivery systems

KW - magnetic polymers

KW - nanocontainers

KW - pH response

KW - temperature response

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Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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