Development of a sensing system to detect C-telopeptide of type-I collagen

Nasrin Afsarimanesh, Asif I. Zia, S. C. Mukhopadhyay, Marlena Kruger, P. L. Yu, Jürgen Kosel

Research output: Chapter in Book/Report/Conference proceedingConference contribution


This research work describes a non-invasive and label-free immunosensing technique to detect the C-telopeptide of type-I collagen (CTX-1) by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital capacitive sensor is used to evaluate the properties of the material under test. This sensor was fabricated on the basis of thin film micro-electromechanical system (MEMS) semiconductor device fabrication technology. EIS was used in conjunction with the sensor to detect collagen type-I in blood plasma. At the first stage, the Serum CrossLaps® ELISA was used to measure some known samples in order to obtain a standard curve. Streptavidin agarose was successfully immobilized on the sensing area of the sensor. After that the experiments were done with antibody solution and three known samples of CTX-1, zero concentration which was considered as control, 2.669 ng/ml and 0.798 ng/ml concentration. The results are encouraging for further investigation.
Original languageEnglish (US)
Title of host publication2015 9th International Conference on Sensing Technology (ICST)
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Number of pages5
ISBN (Print)9781479963140
StatePublished - Mar 30 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01


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