Development and evaluation of a sublingual film of the antiemetic granisetron hydrochloride

Vani Kalia, Tarun Garg, Gautam Rath, Amit Kumar Goyal

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The objective of this study was to develop an oral transmucosal formulation of an antiemetic drug that can not only serve in the active form but also provide a controlled release profile. In this study, sublingual films based on the biodegradable and water-soluble polymers, that is HPMCK-4M and PVPK-30, were developed by the solvent casting method, and were loaded with the antiemetic drug granisetron hydrochloride (granisetron HCl). The entrapment efficiency of the developed formulation was found to be 86%. The in vitro profile showed an instant release of the drug from the sublingual film, in a pattern following the first order kinetics array. The in vivo studies showed that granisetron HCl was delivered in its active state and showed effective results, as compared to its activity in the marketed formulation.
Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume44
Issue number3
DOIs
StatePublished - Apr 2 2016
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Pharmaceutical Science
  • Medicine (miscellaneous)

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