Development and characterization of rifampicin loaded floating microspheres

Pankaj Goyal; S. Gill; U. D. Gupta; Goutam Rath; Raj K. Narang; Amit K. Goyal

doi:10.3109/10731199.2011.573482

Development and characterization of rifampicin loaded floating microspheres

Pankaj Goyal, S. Gill, U. D. Gupta, Goutam Rath, Raj K. Narang, Amit K. Goyal

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. © 2011 Informa Healthcare USA, Inc.

Original language	English (US)
Pages (from-to)	330-334
Number of pages	5
Journal	Artificial Cells, Blood Substitutes, and Biotechnology
Volume	39
Issue number	5
DOIs	https://doi.org/10.3109/10731199.2011.573482
State	Published - Oct 1 2011
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

Biomedical Engineering
Biotechnology

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10.3109/10731199.2011.573482

Cite this

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abstract = "Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. {\textcopyright} 2011 Informa Healthcare USA, Inc.",

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AU - Gill, S.

AU - Gupta, U. D.

AU - Rath, Goutam

AU - Narang, Raj K.

AU - Goyal, Amit K.

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AB - Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. © 2011 Informa Healthcare USA, Inc.

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Development and characterization of rifampicin loaded floating microspheres

Abstract

Bibliographical note

ASJC Scopus subject areas

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