Development and characterization of niosomal gel for topical delivery of benzoyl peroxide

Gagan Goyal, Tarun Garg, Basant Malik, Gaurav Chauhan, Goutam Rath, Amit K. Goyal

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Benzoyl peroxide (BPO) is generally considered as first line treatment against acne. Low water solubility and formation of larger clusters and limited skin permeation upon topical application necessitates the application of high amount of drug for desired action which leads to induction of skin irritation. In the present study, we developed BPO-loaded niosomal formulation to improve its permeation through skin. The niosomes were further loaded in the carbopol gel to improve contact time. The results of the skin permeation study, skin retention study revealed that niosomes can effectively improve the drug permeation through skin. Application of niosomal gel significantly reduced the bacterial load after a treatment of four days. This reduction in bacterial load was further resulted in a significant reduction in the inflammation with minimal skin irritation compared with plain drug and the plain niosomal formulation.
Original languageEnglish (US)
Pages (from-to)1027-1042
Number of pages16
JournalDrug Delivery
Volume22
Issue number8
DOIs
StatePublished - Nov 17 2015
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

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