Development and characterization of nano-fiber patch for the treatment of glaucoma

Gagandeep, Tarun Garg, Basant Malik, Goutam Rath, Amit K. Goyal

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. © 2013 Elsevier B.V. All rights reserved.
Original languageEnglish (US)
Pages (from-to)10-16
Number of pages7
JournalEuropean Journal of Pharmaceutical Sciences
Volume53
Issue number1
DOIs
StatePublished - Mar 12 2014
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Pharmaceutical Science

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