Development and characterization of nano-fiber patch for the treatment of glaucoma

null Gagandeep; Tarun Garg; Basant Malik; Goutam Rath; Amit K. Goyal

doi:10.1016/j.ejps.2013.11.016

Development and characterization of nano-fiber patch for the treatment of glaucoma

Gagandeep, Tarun Garg, Basant Malik, Goutam Rath, Amit K. Goyal

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. © 2013 Elsevier B.V. All rights reserved.

Original language	English (US)
Pages (from-to)	10-16
Number of pages	7
Journal	European Journal of Pharmaceutical Sciences
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/j.ejps.2013.11.016
State	Published - Mar 12 2014
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.ejps.2013.11.016

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title = "Development and characterization of nano-fiber patch for the treatment of glaucoma",

abstract = "In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. {\textcopyright} 2013 Elsevier B.V. All rights reserved.",

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AU - Gagandeep, null

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AU - Malik, Basant

AU - Rath, Goutam

AU - Goyal, Amit K.

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PY - 2014/3/12

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N2 - In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. © 2013 Elsevier B.V. All rights reserved.

AB - In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. © 2013 Elsevier B.V. All rights reserved.

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Development and characterization of nano-fiber patch for the treatment of glaucoma

Abstract

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