Development and application of polymeric monolithic stationary phases for capillary electrochromatography

Emily F. Hilder, Frantisek Svec*, Jean M.J. Fréchet

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

219 Scopus citations


Monolithic columns for capillary electrochromatography are receiving quite remarkable attention. This review summarizes results excerpted from numerous papers concerning this rapidly growing area with a focus on monoliths prepared from synthetic polymers. Both the simplicity of the in situ preparation and the large number of readily available chemistries make the monolithic separation media a vital alternative to capillary columns packed with particulate materials. Therefore, they are now a well-established stationary phase format in the field of capillary electrochromatography. A wide variety of synthetic approaches as well as materials used for the preparation of the monolithic stationary phases are presented in detail. The analytical potential of these columns is demonstrated with separations involving various families of compounds and different chromatographic modes.

Original languageEnglish (US)
Pages (from-to)3-22
Number of pages20
JournalJournal of Chromatography A
Issue number1-2
StatePublished - Jul 30 2004
Externally publishedYes

Bibliographical note

Funding Information:
Support of this work by the National Institute of General Medical Sciences, National Institutes of Health (GM-48364) is gratefully acknowledged.


  • Electrochromatography
  • Monolithic columns
  • Peptides
  • Proteins
  • Reviews
  • Saccharides
  • Stationary phases, electrochromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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