TY - JOUR
T1 - Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode
AU - Muthumariappan, Akilarasan
AU - Govindasamy, Mani
AU - Chen, Shen Ming
AU - Sakthivel, Kogularasu
AU - Mani, Veerappan
AU - Chen, Tse Wei
AU - Selvaraj, Shanthi
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-21
PY - 2017/8/1
Y1 - 2017/8/1
N2 - The development of sensor for azathioprine (ATP) determination is extremely important as its excess level in blood imposes carcinogenic threats. A sensitive, selective, reproducible and durable azathioprine sensor was demonstrated using a nanocomposite composed of Mn3O4 micro cubes and multi-walled carbon nanotubes (MWCNTs/Mn3O4 MCs). The composite was prepared through a facile hydrothermal method and its morphology, elemental, impedance and electrochemical properties were studied. The MWCNTs/Mn3O4 MCs was modified on the screen-printed electrode, and the resulting modified electrode displayed excellent electrocatalytic ability towards ATP and the reduction peak current was related to the concentration of ATP. The working range was 0.045-2530 μM and the detection limit was 4.3 nM (± 2.53). The method was successfully applied to the determination of ATP in spiked samples of human blood serum and tablets.
AB - The development of sensor for azathioprine (ATP) determination is extremely important as its excess level in blood imposes carcinogenic threats. A sensitive, selective, reproducible and durable azathioprine sensor was demonstrated using a nanocomposite composed of Mn3O4 micro cubes and multi-walled carbon nanotubes (MWCNTs/Mn3O4 MCs). The composite was prepared through a facile hydrothermal method and its morphology, elemental, impedance and electrochemical properties were studied. The MWCNTs/Mn3O4 MCs was modified on the screen-printed electrode, and the resulting modified electrode displayed excellent electrocatalytic ability towards ATP and the reduction peak current was related to the concentration of ATP. The working range was 0.045-2530 μM and the detection limit was 4.3 nM (± 2.53). The method was successfully applied to the determination of ATP in spiked samples of human blood serum and tablets.
UR - https://linkinghub.elsevier.com/retrieve/pii/S1452398123115847
UR - http://www.scopus.com/inward/record.url?scp=85028460162&partnerID=8YFLogxK
U2 - 10.20964/2017.08.145
DO - 10.20964/2017.08.145
M3 - Article
SN - 1452-3981
VL - 12
SP - 7446
EP - 7456
JO - International Journal of Electrochemical Science
JF - International Journal of Electrochemical Science
IS - 8
ER -