Designing dendrimers for drug delivery

Mingjun Liu, Jean M.J. Fréchet*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

464 Scopus citations

Abstract

Dendrimers are highly branched three-dimensional macromolecules with highly controlled structures, a single molecular weight, a large number of controllable 'peripheral' functionalities and a tendency to adopt a globular shape once a certain size is reached. These features have made their application in pharmaceutical and medicinal chemistry particularly attractive. This review briefly discusses the preparation of dendrimers, their use as gene delivery agents and magnetic resonance imaging agents, and their potential for applications in drug delivery. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)393-401
Number of pages9
JournalPharmaceutical Science and Technology Today
Volume2
Issue number10
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

Bibliographical note

Funding Information:
We thank our valued collaborator Professor F.C. Szoka (University of California, San Francisco, CA, USA) for stimulating discussions, and Professor R. Duncan (University of London, UK) for sharing unpublished results. Financial support by the National Science Foundation (DMR 9816166) is gratefully acknowledged.

ASJC Scopus subject areas

  • Pharmaceutical Science

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