Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

Britt Marie Swahn; Yafeng Xue; Erwan Arzel; Elisabet Kallin; Angelika Magnus; Niklas Plobeck; Jenny Viklund

doi:10.1016/j.bmcl.2005.11.039

Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

Britt Marie Swahn^*, Yafeng Xue, Erwan Arzel, Elisabet Kallin, Angelika Magnus, Niklas Plobeck, Jenny Viklund

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2′-anilino-4,4′-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.

Original language	English (US)
Pages (from-to)	1397-1401
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2005.11.039
State	Published - Mar 1 2006
Externally published	Yes

Keywords

2′-Anilino-4,4′- bipyridines
JNK3 inhibitors
Structure based design
Structure-activity relationship
c-Jun N-terminal kinase-3

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2005.11.039

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title = "Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3",

abstract = "The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2′-anilino-4,4′-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.",

keywords = "2′-Anilino-4,4′- bipyridines, JNK3 inhibitors, Structure based design, Structure-activity relationship, c-Jun N-terminal kinase-3",

author = "Swahn, {Britt Marie} and Yafeng Xue and Erwan Arzel and Elisabet Kallin and Angelika Magnus and Niklas Plobeck and Jenny Viklund",

year = "2006",

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doi = "10.1016/j.bmcl.2005.11.039",

language = "English (US)",

volume = "16",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

AU - Swahn, Britt Marie

AU - Xue, Yafeng

AU - Arzel, Erwan

AU - Kallin, Elisabet

AU - Magnus, Angelika

AU - Plobeck, Niklas

AU - Viklund, Jenny

PY - 2006/3/1

Y1 - 2006/3/1

N2 - The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2′-anilino-4,4′-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.

AB - The design and synthesis of a new series of c-Jun N-terminal kinase-3 (JNK3) inhibitors with selectivity against JNK1 are reported. The novel series of substituted 2′-anilino-4,4′-bipyridines were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of compounds crystallized into the JNK3 ATP binding active site.

KW - 2′-Anilino-4,4′- bipyridines

KW - JNK3 inhibitors

KW - Structure based design

KW - Structure-activity relationship

KW - c-Jun N-terminal kinase-3

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U2 - 10.1016/j.bmcl.2005.11.039

DO - 10.1016/j.bmcl.2005.11.039

M3 - Article

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AN - SCOPUS:31344479605

SN - 0960-894X

VL - 16

SP - 1397

EP - 1401

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

Abstract

Keywords

ASJC Scopus subject areas

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