Dendritic carrier based on PEG: Design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s

Xiaoshuang Feng; Elliot L. Chaikof; Christelle Absalon; Carlos Drummond; Daniel Taton; Yves Gnanou

doi:10.1002/marc.201100459

Dendritic carrier based on PEG: Design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s

Xiaoshuang Feng, Elliot L. Chaikof, Christelle Absalon, Carlos Drummond, Daniel Taton^*, Yves Gnanou

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Degradable dendrimer-like PEOs were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 k·mol^-1 was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (≈2k·mol^-1), as monitored by ¹H NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.

Original language	English (US)
Pages (from-to)	1722-1728
Number of pages	7
Journal	Macromolecular Rapid Communications
Volume	32
Issue number	21
DOIs	https://doi.org/10.1002/marc.201100459
State	Published - Nov 1 2011
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-21

Keywords

biodegradable
branching
dendrimer
ketal
poly(ethylene oxide)

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1002/marc.201100459

Cite this

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title = "Dendritic carrier based on PEG: Design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s",

abstract = "Degradable dendrimer-like PEOs were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 k·mol-1 was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (≈2k·mol-1), as monitored by 1H NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.",

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AU - Chaikof, Elliot L.

AU - Absalon, Christelle

AU - Drummond, Carlos

AU - Taton, Daniel

AU - Gnanou, Yves

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-21

PY - 2011/11/1

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AB - Degradable dendrimer-like PEOs were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 k·mol-1 was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (≈2k·mol-1), as monitored by 1H NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.

KW - biodegradable

KW - branching

KW - dendrimer

KW - ketal

KW - poly(ethylene oxide)

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Dendritic carrier based on PEG: Design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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