Dendrimers and dendritic polymers in drug delivery

Elizabeth R. Gillies; Jean M.J. Fréchet

doi:10.1016/S1359-6446(04)03276-3

Dendrimers and dendritic polymers in drug delivery

Elizabeth R. Gillies^*, Jean M.J. Fréchet

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1306 Scopus citations

Abstract

The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and well-defined molecular weight, make them promising new scaffolds for drug delivery. In the past decade, research has increased on the design and synthesis of biocompatible dendrimers and their application to many areas of bioscience including drug delivery, immunology and the development of vaccines, antimicrobials and antivirals. Recent progress has been made in the application of biocompatible dendrimers to cancer treatment, including their use as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutron capture therapy and photodynamic therapy.

Original language	English (US)
Pages (from-to)	35-43
Number of pages	9
Journal	Drug Discovery Today
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/S1359-6446(04)03276-3
State	Published - Jan 1 2005
Externally published	Yes

Keywords

Biochemistry
Biocompatible
Boron neutron capture therapy
Cancer
Cancer biology
Dendrimer-drug conjugates
Drug Discovery
Pharmaceutical Science
Photodynamic therapy

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1359-6446(04)03276-3

Cite this

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title = "Dendrimers and dendritic polymers in drug delivery",

abstract = "The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and well-defined molecular weight, make them promising new scaffolds for drug delivery. In the past decade, research has increased on the design and synthesis of biocompatible dendrimers and their application to many areas of bioscience including drug delivery, immunology and the development of vaccines, antimicrobials and antivirals. Recent progress has been made in the application of biocompatible dendrimers to cancer treatment, including their use as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutron capture therapy and photodynamic therapy.",

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AU - Gillies, Elizabeth R.

AU - Fréchet, Jean M.J.

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AB - The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and well-defined molecular weight, make them promising new scaffolds for drug delivery. In the past decade, research has increased on the design and synthesis of biocompatible dendrimers and their application to many areas of bioscience including drug delivery, immunology and the development of vaccines, antimicrobials and antivirals. Recent progress has been made in the application of biocompatible dendrimers to cancer treatment, including their use as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutron capture therapy and photodynamic therapy.

KW - Biochemistry

KW - Biocompatible

KW - Boron neutron capture therapy

KW - Cancer

KW - Cancer biology

KW - Dendrimer-drug conjugates

KW - Drug Discovery

KW - Pharmaceutical Science

KW - Photodynamic therapy

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U2 - 10.1016/S1359-6446(04)03276-3

DO - 10.1016/S1359-6446(04)03276-3

M3 - Review article

C2 - 15676297

AN - SCOPUS:12844258906

SN - 1359-6446

VL - 10

SP - 35

EP - 43

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 1

ER -

Dendrimers and dendritic polymers in drug delivery

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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