Dedifferentiation, transdifferentiation, and reprogramming: Future directions in regenerative medicine

Cristina Eguizabal; Nuria Montserrat; Anna Veiga; Juancarlos Izpisua Belmonte

doi:10.1055/s-0032-1331802

Dedifferentiation, transdifferentiation, and reprogramming: Future directions in regenerative medicine

Cristina Eguizabal, Nuria Montserrat, Anna Veiga, Juancarlos Izpisua Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming). By studying the regenerative processes in both nonmammal and mammal models, natural or artificial processes could underscore the molecular and cellular mechanisms behind these phenomena and be used to create future regenerative strategies for humans.

Original language	English (US)
Pages (from-to)	82-94
Number of pages	13
Journal	Seminars in Reproductive Medicine
Volume	31
Issue number	1
DOIs	https://doi.org/10.1055/s-0032-1331802
State	Published - 2013
Externally published	Yes

Keywords

dedifferentiation
regenerative medicine
reprogramming
stem cells
transdifferentiation

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Reproductive Medicine
Endocrinology
Obstetrics and Gynecology
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-0032-1331802

Cite this

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abstract = "The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming). By studying the regenerative processes in both nonmammal and mammal models, natural or artificial processes could underscore the molecular and cellular mechanisms behind these phenomena and be used to create future regenerative strategies for humans.",

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AU - Montserrat, Nuria

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AU - Belmonte, Juancarlos Izpisua

PY - 2013

Y1 - 2013

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AB - The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming). By studying the regenerative processes in both nonmammal and mammal models, natural or artificial processes could underscore the molecular and cellular mechanisms behind these phenomena and be used to create future regenerative strategies for humans.

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KW - regenerative medicine

KW - reprogramming

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Dedifferentiation, transdifferentiation, and reprogramming: Future directions in regenerative medicine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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