Decoding Electrophysiological Signals with Organic Electrochemical Transistors

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The organic electrochemical transistor (OECT) has unique characteristics that distinguish it from other transistors and make it a promising electronic transducer of biological events. High transconductance, flexibility, and biocompatibility render OECTs ideal for detecting electrophysiological signals. Device properties such as transconductance, response time, and noise level should, however, be optimized to adapt to the needs of various application environments including in vitro cell culture, human skin, and inside of a living system. This review includes an overview of the origin of electrophysiological signals, the working principles of OECTs, and methods for performance optimization. While covering recent research examples of the use of OECTs in electrophysiology, a perspective is provided for next-generation bioelectric sensors and amplifiers for electrophysiology applications.
Original languageEnglish (US)
Pages (from-to)2100187
JournalMacromolecular Bioscience
StatePublished - Aug 30 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-09-02
Acknowledgements: Y.Z. and A.S. contributed equally to this work. A.S. acknowledges King Abdulaziz City for Science and Technology (KACST) student grant RGC/3/3620. The authors thank Andrea Devlin for proofreading the manuscript.

ASJC Scopus subject areas

  • Materials Chemistry
  • Biomaterials
  • Polymers and Plastics
  • Bioengineering
  • Biotechnology


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