Abstract
Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay. © The Rockefeller University Press.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 189-194 |
| Number of pages | 6 |
| Journal | Journal of Cell Biology |
| Volume | 181 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 21 2008 |
| Externally published | Yes |
Bibliographical note
Generated from Scopus record by KAUST IRTS on 2022-09-13ASJC Scopus subject areas
- Cell Biology