Decoding ARE-mediated decay: Is microRNA part of the equation?

Christopher Von Roretz, Imed Eddine Gallouzi

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay. © The Rockefeller University Press.
Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalJournal of Cell Biology
Volume181
Issue number2
DOIs
StatePublished - Apr 21 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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