DDESC: Dragon database for exploration of sodium channels in human

Sunil Sagar; Mandeep Kaur; Adam Dawe; Sundararajan Vijayaraghava Seshadri; Alan Christoffels; Ulf Schaefer; Aleksandar Radovanovic; Vladimir B. Bajic

doi:10.1186/1471-2164-9-622

DDESC: Dragon database for exploration of sodium channels in human

Sunil Sagar, Mandeep Kaur, Adam Dawe, Sundararajan Vijayaraghava Seshadri, Alan Christoffels, Ulf Schaefer, Aleksandar Radovanovic, Vladimir B. Bajic^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. Results: We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. Conclusion: DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels. This database is freely accessible for academic and non-profit users via the worldwide web http://apps.sanbi.ac.za/ddesc.

Original language	English (US)
Article number	622
Journal	BMC genomics
Volume	9
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1186/1471-2164-9-622
State	Published - Dec 20 2008
Externally published	Yes

Bibliographical note

Funding Information:
SS, AD, SVS, AC, are supported fully, and MK, US, AR, VBB partly by the DST/NRF Research Chair grant 64751. MK, US, AR, VBB are supported partly by the National Bioinformatics Network grants. MK has been supported by the postdoctoral fellowship from the Claude Leon Foundation, South Africa. VBB was partly supported by National Research Foundation grants (62302, 61070).

ASJC Scopus subject areas

Biotechnology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1471-2164-9-622

Cite this

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title = "DDESC: Dragon database for exploration of sodium channels in human",

abstract = "Background: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. Results: We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as {"}genes and proteins{"}, {"}metabolites and enzymes{"}, {"}toxins{"}, {"}chemicals with pharmacological effects{"}, {"}disease concepts{"}, {"}human anatomy{"}, {"}pathways and pathway reactions{"} and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. Conclusion: DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels. This database is freely accessible for academic and non-profit users via the worldwide web http://apps.sanbi.ac.za/ddesc.",

author = "Sunil Sagar and Mandeep Kaur and Adam Dawe and Seshadri, {Sundararajan Vijayaraghava} and Alan Christoffels and Ulf Schaefer and Aleksandar Radovanovic and Bajic, {Vladimir B.}",

note = "Funding Information: SS, AD, SVS, AC, are supported fully, and MK, US, AR, VBB partly by the DST/NRF Research Chair grant 64751. MK, US, AR, VBB are supported partly by the National Bioinformatics Network grants. MK has been supported by the postdoctoral fellowship from the Claude Leon Foundation, South Africa. VBB was partly supported by National Research Foundation grants (62302, 61070).",

year = "2008",

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doi = "10.1186/1471-2164-9-622",

language = "English (US)",

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AU - Sagar, Sunil

AU - Kaur, Mandeep

AU - Dawe, Adam

AU - Seshadri, Sundararajan Vijayaraghava

AU - Christoffels, Alan

AU - Schaefer, Ulf

AU - Radovanovic, Aleksandar

AU - Bajic, Vladimir B.

N1 - Funding Information: SS, AD, SVS, AC, are supported fully, and MK, US, AR, VBB partly by the DST/NRF Research Chair grant 64751. MK, US, AR, VBB are supported partly by the National Bioinformatics Network grants. MK has been supported by the postdoctoral fellowship from the Claude Leon Foundation, South Africa. VBB was partly supported by National Research Foundation grants (62302, 61070).

PY - 2008/12/20

Y1 - 2008/12/20

N2 - Background: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. Results: We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. Conclusion: DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels. This database is freely accessible for academic and non-profit users via the worldwide web http://apps.sanbi.ac.za/ddesc.

AB - Background: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. Results: We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. Conclusion: DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels. This database is freely accessible for academic and non-profit users via the worldwide web http://apps.sanbi.ac.za/ddesc.

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DDESC: Dragon database for exploration of sodium channels in human

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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