Database for exploration of functional context of genes implicated in ovarian cancer

Mandeep Kaur, Aleksandar Radovanovic, Magbubah Essack, Ulf Schaefer, Monique Maqungo, Tracey Kibler, Sebastian Schmeier, Alan Christoffels, Kothandaraman Narasimhan, Mahesh Choolani, Vladimir B. Bajic*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Ovarian cancer (OC) is becoming the most common gynecological cancer in developed countries and the most lethal gynecological malignancy. It is also the fifth leading cause of all cancer-related deaths in women. The identification of diagnostic biomarkers and development of early detection techniques for OC largely depends on the understanding of the complex functionality and regulation of genes involved in this disease. Unfortunately, information about these OC genes is scattered throughout the literature and various databases making extraction of relevant functional information a complex task. To reduce this problem, we have developed a database dedicated to OC genes to support exploration of functional characterization and analysis of biological processes related to OC. The database contains general information about OC genes, enriched with the results of transcription regulation sequence analysis and with relevant text mining to provide insights into associations of the OC genes with other genes, metabolites, pathways and nuclear proteins. Overall, it enables exploration of relevant information for OC genes from multiple angles, making it a unique resource for OC and will serve as a useful complement to the existing public resources for those interested in OC genetics. Access is free for academic and non-profit users and database can be accessed at http://apps.sanbi.ac.za/ddoc/.

Original languageEnglish (US)
Pages (from-to)D820-D823
JournalNUCLEIC ACIDS RESEARCH
Volume37
Issue numberSUPPL. 1
DOIs
StatePublished - 2009

Bibliographical note

Funding Information:
National Bioinformatics Network grants (to A.R., U.S., M.M., S.S. and V.B.B.) partially; National Research Foundation (61070 to M.M. and V.B.B.) partially; DST/NRF Research Chair (64751 to V.B.B.) and National Research Foundation (62302 to V.B.B.) partially. Funding for open access charge: National Bioinformatics Network grants.

Funding Information:
M.K. has been supported by the postdoctoral fellowship from the Claude Leon Foundation, South Africa.

ASJC Scopus subject areas

  • Genetics

Fingerprint

Dive into the research topics of 'Database for exploration of functional context of genes implicated in ovarian cancer'. Together they form a unique fingerprint.

Cite this