Data integration in the era of omics: current and future challenges

David Gomez-Cabrero; Imad Abugessaisa; Dieter Maier; Andrew Teschendorff; Matthias Merkenschlager; Andreas Gisel; Esteban Ballestar; Erik Bongcam-Rudloff; Ana Conesa; Jesper Tegnér

doi:10.1186/1752-0509-8-S2-I1

Data integration in the era of omics: current and future challenges

David Gomez-Cabrero, Imad Abugessaisa, Dieter Maier, Andrew Teschendorff, Matthias Merkenschlager, Andreas Gisel, Esteban Ballestar, Erik Bongcam-Rudloff, Ana Conesa, Jesper Tegnér

Research output: Contribution to journal › Review article › peer-review

292 Scopus citations

Abstract

To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through large-scale consortia projects, biological systems are being further investigated at an unprecedented scale generating heterogeneous and often large data sets. These data-sets encourage researchers to develop novel data integration methodologies. In this introduction we review the definition and characterize current efforts on data integration in the life sciences. We have used a web-survey to assess current research projects on data-integration to tap into the views, needs and challenges as currently perceived by parts of the research community.

Original language	English (US)
Pages (from-to)	I1
Journal	BMC SYSTEMS BIOLOGY
Volume	8
DOIs	https://doi.org/10.1186/1752-0509-8-S2-I1
State	Published - 2014
Externally published	Yes

Bibliographical note

Funding Information:
We would like to sincerely thank PhD Gordon Ball and PhD Ali Mortazavi for the constructive review of the manuscript. The supplement originated thanks to a Workshop co-organised by EU FP7 306000 STATegra and SeqAhead COST Action BM1006. The contribution of DGC, IA, DM, MM, EB, AC and JT was supported by EU FP7 306000 STATegra. The contribution of DGC was also supported by BILS (http://www.bils.se). The contribution of AG, EB and AC was supported by EU COST Action BM1006: SeqAhead. The contribution of AG and EB-R was supported by EU FP7 289452 ALLBIO. The contribution of JT was also supported by Stockholm County Council, and the Swedish Research Council. The contribution of IA was also supported by Åke Wibergs Stiftelsen medicine research Diarienr: 719593091 (http://ake-wiberg.se/).

ASJC Scopus subject areas

Structural Biology
Modeling and Simulation
Molecular Biology
Computer Science Applications
Applied Mathematics

Access to Document

10.1186/1752-0509-8-S2-I1

Cite this

@article{423658d355394c25b1793611c4276059,

title = "Data integration in the era of omics: current and future challenges",

abstract = "To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through large-scale consortia projects, biological systems are being further investigated at an unprecedented scale generating heterogeneous and often large data sets. These data-sets encourage researchers to develop novel data integration methodologies. In this introduction we review the definition and characterize current efforts on data integration in the life sciences. We have used a web-survey to assess current research projects on data-integration to tap into the views, needs and challenges as currently perceived by parts of the research community. ",

author = "David Gomez-Cabrero and Imad Abugessaisa and Dieter Maier and Andrew Teschendorff and Matthias Merkenschlager and Andreas Gisel and Esteban Ballestar and Erik Bongcam-Rudloff and Ana Conesa and Jesper Tegn{\'e}r",

note = "Funding Information: We would like to sincerely thank PhD Gordon Ball and PhD Ali Mortazavi for the constructive review of the manuscript. The supplement originated thanks to a Workshop co-organised by EU FP7 306000 STATegra and SeqAhead COST Action BM1006. The contribution of DGC, IA, DM, MM, EB, AC and JT was supported by EU FP7 306000 STATegra. The contribution of DGC was also supported by BILS (http://www.bils.se). The contribution of AG, EB and AC was supported by EU COST Action BM1006: SeqAhead. The contribution of AG and EB-R was supported by EU FP7 289452 ALLBIO. The contribution of JT was also supported by Stockholm County Council, and the Swedish Research Council. The contribution of IA was also supported by {\AA}ke Wibergs Stiftelsen medicine research Diarienr: 719593091 (http://ake-wiberg.se/).",

year = "2014",

doi = "10.1186/1752-0509-8-S2-I1",

language = "English (US)",

volume = "8",

pages = "I1",

journal = "BMC SYSTEMS BIOLOGY",

issn = "1752-0509",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - Data integration in the era of omics

T2 - current and future challenges

AU - Gomez-Cabrero, David

AU - Abugessaisa, Imad

AU - Maier, Dieter

AU - Teschendorff, Andrew

AU - Merkenschlager, Matthias

AU - Gisel, Andreas

AU - Ballestar, Esteban

AU - Bongcam-Rudloff, Erik

AU - Conesa, Ana

AU - Tegnér, Jesper

N1 - Funding Information: We would like to sincerely thank PhD Gordon Ball and PhD Ali Mortazavi for the constructive review of the manuscript. The supplement originated thanks to a Workshop co-organised by EU FP7 306000 STATegra and SeqAhead COST Action BM1006. The contribution of DGC, IA, DM, MM, EB, AC and JT was supported by EU FP7 306000 STATegra. The contribution of DGC was also supported by BILS (http://www.bils.se). The contribution of AG, EB and AC was supported by EU COST Action BM1006: SeqAhead. The contribution of AG and EB-R was supported by EU FP7 289452 ALLBIO. The contribution of JT was also supported by Stockholm County Council, and the Swedish Research Council. The contribution of IA was also supported by Åke Wibergs Stiftelsen medicine research Diarienr: 719593091 (http://ake-wiberg.se/).

PY - 2014

Y1 - 2014

N2 - To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through large-scale consortia projects, biological systems are being further investigated at an unprecedented scale generating heterogeneous and often large data sets. These data-sets encourage researchers to develop novel data integration methodologies. In this introduction we review the definition and characterize current efforts on data integration in the life sciences. We have used a web-survey to assess current research projects on data-integration to tap into the views, needs and challenges as currently perceived by parts of the research community.

AB - To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through large-scale consortia projects, biological systems are being further investigated at an unprecedented scale generating heterogeneous and often large data sets. These data-sets encourage researchers to develop novel data integration methodologies. In this introduction we review the definition and characterize current efforts on data integration in the life sciences. We have used a web-survey to assess current research projects on data-integration to tap into the views, needs and challenges as currently perceived by parts of the research community.

UR - http://www.scopus.com/inward/record.url?scp=85005877161&partnerID=8YFLogxK

U2 - 10.1186/1752-0509-8-S2-I1

DO - 10.1186/1752-0509-8-S2-I1

M3 - Review article

C2 - 25032990

AN - SCOPUS:85005877161

SN - 1752-0509

VL - 8

SP - I1

JO - BMC SYSTEMS BIOLOGY

JF - BMC SYSTEMS BIOLOGY

ER -

Data integration in the era of omics: current and future challenges

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this