TY - JOUR
T1 - DAMPD: A manually curated antimicrobial peptide database
AU - Seshadri Sundararajan, Vijayaraghava
AU - Gabere, Musa Nur
AU - Pretorius, Ashley
AU - Adam, Saleem
AU - Christoffels, Alan
AU - Lehvaslaiho, Minna
AU - Archer, John A.C.
AU - Bajic, Vladimir B.
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2011/11/21
Y1 - 2011/11/21
N2 - The demand for antimicrobial peptides (AMPs) is rising because of the increased occurrence of pathogens that are tolerant or resistant to conventional antibiotics. Since naturally occurring AMPs could serve as templates for the development of new anti-infectious agents to which pathogens are not resistant, a resource that contains relevant information on AMP is of great interest. To that extent, we developed the Dragon Antimicrobial Peptide Database (DAMPD, http://apps.sanbi.ac.za/dampd) that contains 1232 manually curated AMPs. DAMPD is an update and a replacement of the ANTIMIC database. In DAMPD an integrated interface allows in a simple fashion querying based on taxonomy, species, AMP family, citation, keywords and a combination of search terms and fields (Advanced Search). A number of tools such as Blast, ClustalW, HMMER, Hydrocalculator, SignalP, AMP predictor, as well as a number of other resources that provide additional information about the results are also provided and integrated into DAMPD to augment biological analysis of AMPs. The Author(s) 2011. Published by Oxford University Press.
AB - The demand for antimicrobial peptides (AMPs) is rising because of the increased occurrence of pathogens that are tolerant or resistant to conventional antibiotics. Since naturally occurring AMPs could serve as templates for the development of new anti-infectious agents to which pathogens are not resistant, a resource that contains relevant information on AMP is of great interest. To that extent, we developed the Dragon Antimicrobial Peptide Database (DAMPD, http://apps.sanbi.ac.za/dampd) that contains 1232 manually curated AMPs. DAMPD is an update and a replacement of the ANTIMIC database. In DAMPD an integrated interface allows in a simple fashion querying based on taxonomy, species, AMP family, citation, keywords and a combination of search terms and fields (Advanced Search). A number of tools such as Blast, ClustalW, HMMER, Hydrocalculator, SignalP, AMP predictor, as well as a number of other resources that provide additional information about the results are also provided and integrated into DAMPD to augment biological analysis of AMPs. The Author(s) 2011. Published by Oxford University Press.
UR - http://hdl.handle.net/10754/325451
UR - https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkr1063
UR - http://www.scopus.com/inward/record.url?scp=84862201368&partnerID=8YFLogxK
U2 - 10.1093/nar/gkr1063
DO - 10.1093/nar/gkr1063
M3 - Article
C2 - 22110032
SN - 0305-1048
VL - 40
SP - D1108-D1112
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -