Cu(II)-Catalyzed, Site Selective Sulfoximination to Indole and Indolines via Dual C–H/N–H Activation

Mohit Kumar, Anushka Rastogi, Raziullah, Ashfaq Ahmad, Manoj Kumar Gangwar, Dipankar Koley

Research output: Contribution to journalArticlepeer-review


A copper-catalyzed protocol furnishing N-arylated sulfoximines has been developed via dual N-H/C-H activation. Arylalkyl- and less reactive diarylsulfoximines were efficiently coupled with privileged scaffolds like indolines, indoles, and N-Ar-7-azaindoles. Sulfoximines based on medicinally relevant scaffolds (phenothiazine, dibenzothiophene, thioxanthenone) were also well tolerated. Detailed mechanistic studies indicate that the deprotometalation and protodemetalation step is the reversible step.
Original languageEnglish (US)
JournalOrganic Letters
StatePublished - Nov 29 2022

Bibliographical note

KAUST Repository Item: Exported on 2022-12-01
Acknowledgements: Financial support from CSIR (NISTHA, MPL-2034), UGC-New Delhi (R. and M.K.), and CSIR-New Delhi (A.A. and A.R.) is gratefully acknowledged. We thank the CDRI SAIF division for analytical support. We thank Dr. Benudhar Punji, CSIR-NCL, for his helpful suggestion. CDRI Communication no 10500.

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry


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