A copper-catalyzed protocol furnishing N-arylated sulfoximines has been developed via dual N-H/C-H activation. Arylalkyl- and less reactive diarylsulfoximines were efficiently coupled with privileged scaffolds like indolines, indoles, and N-Ar-7-azaindoles. Sulfoximines based on medicinally relevant scaffolds (phenothiazine, dibenzothiophene, thioxanthenone) were also well tolerated. Detailed mechanistic studies indicate that the deprotometalation and protodemetalation step is the reversible step.
|Original language||English (US)|
|State||Published - Nov 29 2022|
Bibliographical noteKAUST Repository Item: Exported on 2022-12-01
Acknowledgements: Financial support from CSIR (NISTHA, MPL-2034), UGC-New Delhi (R. and M.K.), and CSIR-New Delhi (A.A. and A.R.) is gratefully acknowledged. We thank the CDRI SAIF division for analytical support. We thank Dr. Benudhar Punji, CSIR-NCL, for his helpful suggestion. CDRI Communication no 10500.
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry