Cross-Coupling of Sodium Sulfinates with Aryl, Heteroaryl and Vinyl Halides by Nickel/photoredox dual catalysis

Huifeng Yue; Chen Zhu; Magnus Rueping

doi:10.1002/anie.201711104

Cross-Coupling of Sodium Sulfinates with Aryl, Heteroaryl and Vinyl Halides by Nickel/photoredox dual catalysis

Huifeng Yue, Chen Zhu, Magnus Rueping

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

An efficient photoredox/nickel dual catalyzed sulfonylation reaction of aryl, heteroaryl, and vinyl halides has been achieved for the first time. This newly developed sulfonylation protocol provides a versatile method for the synthesis of diverse aromatic sulfones at room temperature and shows excellent functional group tolerance. The electrophilic coupling partners are not limited to aryl, heteroaryl and vinyl bromides but also less reactive aryl chlorides are suitable substrates for this transformation.

Original language	English (US)
Pages (from-to)	1371-1375
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	57
Issue number	5
DOIs	https://doi.org/10.1002/anie.201711104 https://doi.org/10.1002/ange.201711104
State	Published - Jan 5 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: H.Y. acknowledges the China Scholarship Council. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement no. 617044 (SunCatChem).

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title = "Cross-Coupling of Sodium Sulfinates with Aryl, Heteroaryl and Vinyl Halides by Nickel/photoredox dual catalysis",

abstract = "An efficient photoredox/nickel dual catalyzed sulfonylation reaction of aryl, heteroaryl, and vinyl halides has been achieved for the first time. This newly developed sulfonylation protocol provides a versatile method for the synthesis of diverse aromatic sulfones at room temperature and shows excellent functional group tolerance. The electrophilic coupling partners are not limited to aryl, heteroaryl and vinyl bromides but also less reactive aryl chlorides are suitable substrates for this transformation.",

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note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: H.Y. acknowledges the China Scholarship Council. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement no. 617044 (SunCatChem).",

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AU - Zhu, Chen

AU - Rueping, Magnus

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: H.Y. acknowledges the China Scholarship Council. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement no. 617044 (SunCatChem).

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N2 - An efficient photoredox/nickel dual catalyzed sulfonylation reaction of aryl, heteroaryl, and vinyl halides has been achieved for the first time. This newly developed sulfonylation protocol provides a versatile method for the synthesis of diverse aromatic sulfones at room temperature and shows excellent functional group tolerance. The electrophilic coupling partners are not limited to aryl, heteroaryl and vinyl bromides but also less reactive aryl chlorides are suitable substrates for this transformation.

AB - An efficient photoredox/nickel dual catalyzed sulfonylation reaction of aryl, heteroaryl, and vinyl halides has been achieved for the first time. This newly developed sulfonylation protocol provides a versatile method for the synthesis of diverse aromatic sulfones at room temperature and shows excellent functional group tolerance. The electrophilic coupling partners are not limited to aryl, heteroaryl and vinyl bromides but also less reactive aryl chlorides are suitable substrates for this transformation.

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Cross-Coupling of Sodium Sulfinates with Aryl, Heteroaryl and Vinyl Halides by Nickel/photoredox dual catalysis

Abstract

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