CRISPR/Cas13 as a Tool for RNA Interference

Zahir Ali; Ahmed Mahas; Magdy M. Mahfouz

doi:10.1016/j.tplants.2018.03.003

CRISPR/Cas13 as a Tool for RNA Interference

Zahir Ali, Ahmed Mahas, Magdy M. Mahfouz

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64 Scopus citations

Abstract

Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.

Original language	English (US)
Pages (from-to)	374-378
Number of pages	5
Journal	Trends in Plant Science
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.tplants.2018.03.003
State	Published - Mar 28 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): OSR-2015-CRG4-2647
Acknowledgements: We wish to thank the Office of Sponsored Research (OSR) and King Abdullah University of Science and Technology (KAUST) for their support (award OSR-2015-CRG4-2647).

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10.1016/j.tplants.2018.03.003

https://repository.kaust.edu.sa/bitstream/10754/627624/1/Mahfouz_Editors%20comments-Revised.pdf

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title = "CRISPR/Cas13 as a Tool for RNA Interference",

abstract = "Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.",

author = "Zahir Ali and Ahmed Mahas and Mahfouz, {Magdy M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): OSR-2015-CRG4-2647 Acknowledgements: We wish to thank the Office of Sponsored Research (OSR) and King Abdullah University of Science and Technology (KAUST) for their support (award OSR-2015-CRG4-2647).",

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doi = "10.1016/j.tplants.2018.03.003",

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T1 - CRISPR/Cas13 as a Tool for RNA Interference

AU - Ali, Zahir

AU - Mahas, Ahmed

AU - Mahfouz, Magdy M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): OSR-2015-CRG4-2647 Acknowledgements: We wish to thank the Office of Sponsored Research (OSR) and King Abdullah University of Science and Technology (KAUST) for their support (award OSR-2015-CRG4-2647).

PY - 2018/3/28

Y1 - 2018/3/28

N2 - Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.

AB - Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.

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UR - http://www.sciencedirect.com/science/article/pii/S1360138518300451

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JO - Trends in Plant Science

JF - Trends in Plant Science

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ER -

CRISPR/Cas13 as a Tool for RNA Interference

Abstract

Bibliographical note

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