Co3O4-cored carbon dots for chemiluminescence analysis of intracellular hydrogen peroxide

Junyu Zhou, Jiangjiang Gu, Chunxiu Tian, Dechen Jiang, Yun Chen*, Kai Xi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Co3O4-cored carbon dots were prepared to induce chemiluminescence from the carbon dots in the presence of hydrogen peroxide at neutral pH. Neither a strong oxidative agent nor alkaline was needed as a co-reactant, which permitted for the first time the application of CDs for such chemiluminescence analysis of cells. The detection limit of hydrogen peroxide was determined to be 10 μM. Due to their good cellular permeability and low cytotoxicity, these nanoparticles were loaded into cells. The greater luminescence observed in cells with elevated intracellular hydrogen peroxide levels showed that our probe could measure the change in concentration of hydrogen peroxide inside cells.

Original languageEnglish (US)
Pages (from-to)39480-39483
Number of pages4
JournalRSC Advances
Issue number45
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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