Copper catalyzed C-H functionalization for direct Mannich reactions

Magnus Rueping; Nikita Tolstoluzhsky

doi:10.1021/ol103150g

Copper catalyzed C-H functionalization for direct Mannich reactions

Magnus Rueping^*, Nikita Tolstoluzhsky

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

A protocol for a practical and direct addition of α-and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.(Figure Presented)

Original language	English (US)
Pages (from-to)	1095-1097
Number of pages	3
Journal	Organic Letters
Volume	13
Issue number	5
DOIs	https://doi.org/10.1021/ol103150g
State	Published - Mar 4 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol103150g

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title = "Copper catalyzed C-H functionalization for direct Mannich reactions",

abstract = "A protocol for a practical and direct addition of α-and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.(Figure Presented)",

author = "Magnus Rueping and Nikita Tolstoluzhsky",

year = "2011",

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doi = "10.1021/ol103150g",

language = "English (US)",

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journal = "Organic Letters",

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T1 - Copper catalyzed C-H functionalization for direct Mannich reactions

AU - Rueping, Magnus

AU - Tolstoluzhsky, Nikita

PY - 2011/3/4

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N2 - A protocol for a practical and direct addition of α-and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.(Figure Presented)

AB - A protocol for a practical and direct addition of α-and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.(Figure Presented)

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U2 - 10.1021/ol103150g

DO - 10.1021/ol103150g

M3 - Article

C2 - 21288008

AN - SCOPUS:79952150244

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VL - 13

SP - 1095

EP - 1097

JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

Copper catalyzed C-H functionalization for direct Mannich reactions

Abstract

ASJC Scopus subject areas

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