Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds

Konstantin Bukhriakov, Victor G. Desyatkin, Valentin Rodionov

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A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of substrates and does not require low temperatures, inert atmospheres, or an aqueous workup. A catalytic mechanism based on nitro group-mediated silyl cation transfer has been proposed. © The Royal Society of Chemistry 2016.
Original languageEnglish (US)
Pages (from-to)7576-7579
Number of pages4
JournalChem. Commun.
Issue number48
StatePublished - 2016

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