Cooperation of biological and mechanical signals in cardiac progenitor cell differentiation

Stefania Pagliari, Ana Cristina Vilela-Silva, Giancarlo Forte, Francesca Pagliari, Corrado Mandoli, Giovanni Vozzi, Stefano Pietronave, Maria Prat, Silvia Licoccia, Arti Ahluwalia, Enrico Traversa*, Marilena Minieri, Paolo Di Nardo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Three-dimensional cardiac tissue-specific scaffolds made of poly-lactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac-like stiffness. The mechano-physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.

Original languageEnglish (US)
Pages (from-to)514-518
Number of pages5
JournalAdvanced Materials
Issue number4
StatePublished - Jan 25 2011
Externally publishedYes


  • 3D scaffold
  • cardiac progenitor cells
  • cardiac tissue engineering

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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