Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

Peter Siman; Subramanian Vedhanarayanan Karthikeyan; Miroslav Nikolov; Wolfgang Fischle; Ashraf Brik

doi:10.1002/anie.201303844

Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

Peter Siman, Subramanian Vedhanarayanan Karthikeyan, Miroslav Nikolov, Wolfgang Fischle, Ashraf Brik^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.

Original language	English (US)
Pages (from-to)	8059-8063
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	31
DOIs	https://doi.org/10.1002/anie.201303844
State	Published - Jul 29 2013
Externally published	Yes

Keywords

H2B protein
chromatin
peptide ligation
proteins
ubiquitination

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201303844

Cite this

@article{3e3a7e48ad32455ba08c1bd0a18f9e5a,

title = "Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34",

abstract = "As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.",

keywords = "H2B protein, chromatin, peptide ligation, proteins, ubiquitination",

author = "Peter Siman and Karthikeyan, {Subramanian Vedhanarayanan} and Miroslav Nikolov and Wolfgang Fischle and Ashraf Brik",

year = "2013",

month = jul,

day = "29",

doi = "10.1002/anie.201303844",

language = "English (US)",

volume = "52",

pages = "8059--8063",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "Wiley",

number = "31",

}

TY - JOUR

T1 - Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

AU - Siman, Peter

AU - Karthikeyan, Subramanian Vedhanarayanan

AU - Nikolov, Miroslav

AU - Fischle, Wolfgang

AU - Brik, Ashraf

PY - 2013/7/29

Y1 - 2013/7/29

N2 - As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.

AB - As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.

KW - H2B protein

KW - chromatin

KW - peptide ligation

KW - proteins

KW - ubiquitination

UR - http://www.scopus.com/inward/record.url?scp=84880816458&partnerID=8YFLogxK

U2 - 10.1002/anie.201303844

DO - 10.1002/anie.201303844

M3 - Article

C2 - 23794525

AN - SCOPUS:84880816458

SN - 1433-7851

VL - 52

SP - 8059

EP - 8063

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 31

ER -

Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this