Controlling epileptiform activity with organic electronic ion pumps

Adam Williamson; Jonathan Rivnay; Loïg Kergoat; Amanda Jonsson; Sahika Inal; Ilke Uguz; Marc Ferro; Anton Ivanov; Theresia Arbring Sjöström; Daniel T. Simon; Magnus Berggren; George G. Malliaras; Christophe Bernard

doi:10.1002/adma.201500482

Controlling epileptiform activity with organic electronic ion pumps

Adam Williamson, Jonathan Rivnay, Loïg Kergoat, Amanda Jonsson, Sahika Inal, Ilke Uguz, Marc Ferro, Anton Ivanov, Theresia Arbring Sjöström, Daniel T. Simon, Magnus Berggren, George G. Malliaras^*, Christophe Bernard

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

Original language	English (US)
Pages (from-to)	3138-3144
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	20
DOIs	https://doi.org/10.1002/adma.201500482
State	Published - May 1 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

PEDOT:PSS
neuroengineering
organic bioelectronics
organic electronic ion pumps

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201500482

Cite this

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title = "Controlling epileptiform activity with organic electronic ion pumps",

abstract = "In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.",

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AU - Williamson, Adam

AU - Rivnay, Jonathan

AU - Kergoat, Loïg

AU - Jonsson, Amanda

AU - Inal, Sahika

AU - Uguz, Ilke

AU - Ferro, Marc

AU - Ivanov, Anton

AU - Sjöström, Theresia Arbring

AU - Simon, Daniel T.

AU - Berggren, Magnus

AU - Malliaras, George G.

AU - Bernard, Christophe

PY - 2015/5/1

Y1 - 2015/5/1

N2 - In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

AB - In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

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KW - neuroengineering

KW - organic bioelectronics

KW - organic electronic ion pumps

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ER -

Controlling epileptiform activity with organic electronic ion pumps

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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