Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device

Fatemeh Nazly Pirmoradi; Kevin Ou; John K. Jackson; Kevin Letchford; Jing Cui; Ki Tae Wolf; Florian Graber; Tom Zhao; Joanne A. Matsubara; Helen Burt; Mu Chiao; Liwei Lin

doi:10.1109/MEMSYS.2013.6474161

Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device

Fatemeh Nazly Pirmoradi, Kevin Ou, John K. Jackson, Kevin Letchford, Jing Cui, Ki Tae Wolf, Florian Graber, Tom Zhao, Joanne A. Matsubara, Helen Burt, Mu Chiao, Liwei Lin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

8 Scopus citations

Abstract

We demonstrate an implantable MEMS drug delivery device to conduct controlled and on-demand, ex vivo drug transport to human eye tissue. Remotely operated drug delivery to human post-mortem eyes was performed via a MEMS device. The developed curved packaging cover conforms to the eyeball thereby preventing the eye tissue from contacting the actuating membrane. By pulsed operation of the device, using an externally applied magnetic field, the drug released from the device accumulates in a cavity adjacent to the tissue. As such, docetaxel (DTX), an antiangiogenic drug, diffuses through the eye tissue, from sclera and choroid to retina. DTX uptake by sclera and choroid were measured to be 1.93±0.66 and 7.24±0.37 μg/g tissue, respectively, after two hours in pulsed operation mode (10s on/off cycles) at 23°C. During this period, a total amount of 192 ng DTX diffused into the exposed tissue. This MEMS device shows great potential for the treatment of ocular posterior segment diseases such as diabetic retinopathy by introducing a novel way of drug administration to the eye. © 2013 IEEE.

Original language	English (US)
Title of host publication	2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	1-4
Number of pages	4
ISBN (Print)	9781467356558
DOIs	https://doi.org/10.1109/MEMSYS.2013.6474161
State	Published - Jan 2013
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was funded in part by the CollaborativeHealth Research Projects, Natural Science andEngineering Research Council of Canada, the CanadianInstitutes of Health Research, and an AcademicExcellence Alliance grant awarded by the KAUST Officeof Competitive Research Funds. Mu Chiao is supportedby the Canada Research Chairs Program. Authors wouldlike to thank Mr. Tom Brubaker and Ms. Kye Lee,undergraduate students in the Lin lab, for their assistance.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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10.1109/MEMSYS.2013.6474161

Cite this

Pirmoradi, F. N., Ou, K., Jackson, J. K., Letchford, K., Cui, J., Wolf, K. T., Graber, F., Zhao, T., Matsubara, J. A., Burt, H., Chiao, M., & Lin, L. (2013). Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device. In 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 1-4). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/MEMSYS.2013.6474161

@inproceedings{7f722a5b68974ac79762bd56e8c5c4aa,

title = "Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device",

abstract = "We demonstrate an implantable MEMS drug delivery device to conduct controlled and on-demand, ex vivo drug transport to human eye tissue. Remotely operated drug delivery to human post-mortem eyes was performed via a MEMS device. The developed curved packaging cover conforms to the eyeball thereby preventing the eye tissue from contacting the actuating membrane. By pulsed operation of the device, using an externally applied magnetic field, the drug released from the device accumulates in a cavity adjacent to the tissue. As such, docetaxel (DTX), an antiangiogenic drug, diffuses through the eye tissue, from sclera and choroid to retina. DTX uptake by sclera and choroid were measured to be 1.93±0.66 and 7.24±0.37 μg/g tissue, respectively, after two hours in pulsed operation mode (10s on/off cycles) at 23°C. During this period, a total amount of 192 ng DTX diffused into the exposed tissue. This MEMS device shows great potential for the treatment of ocular posterior segment diseases such as diabetic retinopathy by introducing a novel way of drug administration to the eye. {\textcopyright} 2013 IEEE.",

author = "Pirmoradi, {Fatemeh Nazly} and Kevin Ou and Jackson, {John K.} and Kevin Letchford and Jing Cui and Wolf, {Ki Tae} and Florian Graber and Tom Zhao and Matsubara, {Joanne A.} and Helen Burt and Mu Chiao and Liwei Lin",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was funded in part by the CollaborativeHealth Research Projects, Natural Science andEngineering Research Council of Canada, the CanadianInstitutes of Health Research, and an AcademicExcellence Alliance grant awarded by the KAUST Officeof Competitive Research Funds. Mu Chiao is supportedby the Canada Research Chairs Program. Authors wouldlike to thank Mr. Tom Brubaker and Ms. Kye Lee,undergraduate students in the Lin lab, for their assistance. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2013",

month = jan,

doi = "10.1109/MEMSYS.2013.6474161",

language = "English (US)",

isbn = "9781467356558",

pages = "1--4",

booktitle = "2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

}

Pirmoradi, FN, Ou, K, Jackson, JK, Letchford, K, Cui, J, Wolf, KT, Graber, F, Zhao, T, Matsubara, JA, Burt, H, Chiao, M & Lin, L 2013, Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device. in 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). Institute of Electrical and Electronics Engineers (IEEE), pp. 1-4. https://doi.org/10.1109/MEMSYS.2013.6474161

Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device. / Pirmoradi, Fatemeh Nazly; Ou, Kevin; Jackson, John K. et al.
2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). Institute of Electrical and Electronics Engineers (IEEE), 2013. p. 1-4.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device

AU - Pirmoradi, Fatemeh Nazly

AU - Ou, Kevin

AU - Jackson, John K.

AU - Letchford, Kevin

AU - Cui, Jing

AU - Wolf, Ki Tae

AU - Graber, Florian

AU - Zhao, Tom

AU - Matsubara, Joanne A.

AU - Burt, Helen

AU - Chiao, Mu

AU - Lin, Liwei

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was funded in part by the CollaborativeHealth Research Projects, Natural Science andEngineering Research Council of Canada, the CanadianInstitutes of Health Research, and an AcademicExcellence Alliance grant awarded by the KAUST Officeof Competitive Research Funds. Mu Chiao is supportedby the Canada Research Chairs Program. Authors wouldlike to thank Mr. Tom Brubaker and Ms. Kye Lee,undergraduate students in the Lin lab, for their assistance. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2013/1

Y1 - 2013/1

N2 - We demonstrate an implantable MEMS drug delivery device to conduct controlled and on-demand, ex vivo drug transport to human eye tissue. Remotely operated drug delivery to human post-mortem eyes was performed via a MEMS device. The developed curved packaging cover conforms to the eyeball thereby preventing the eye tissue from contacting the actuating membrane. By pulsed operation of the device, using an externally applied magnetic field, the drug released from the device accumulates in a cavity adjacent to the tissue. As such, docetaxel (DTX), an antiangiogenic drug, diffuses through the eye tissue, from sclera and choroid to retina. DTX uptake by sclera and choroid were measured to be 1.93±0.66 and 7.24±0.37 μg/g tissue, respectively, after two hours in pulsed operation mode (10s on/off cycles) at 23°C. During this period, a total amount of 192 ng DTX diffused into the exposed tissue. This MEMS device shows great potential for the treatment of ocular posterior segment diseases such as diabetic retinopathy by introducing a novel way of drug administration to the eye. © 2013 IEEE.

AB - We demonstrate an implantable MEMS drug delivery device to conduct controlled and on-demand, ex vivo drug transport to human eye tissue. Remotely operated drug delivery to human post-mortem eyes was performed via a MEMS device. The developed curved packaging cover conforms to the eyeball thereby preventing the eye tissue from contacting the actuating membrane. By pulsed operation of the device, using an externally applied magnetic field, the drug released from the device accumulates in a cavity adjacent to the tissue. As such, docetaxel (DTX), an antiangiogenic drug, diffuses through the eye tissue, from sclera and choroid to retina. DTX uptake by sclera and choroid were measured to be 1.93±0.66 and 7.24±0.37 μg/g tissue, respectively, after two hours in pulsed operation mode (10s on/off cycles) at 23°C. During this period, a total amount of 192 ng DTX diffused into the exposed tissue. This MEMS device shows great potential for the treatment of ocular posterior segment diseases such as diabetic retinopathy by introducing a novel way of drug administration to the eye. © 2013 IEEE.

UR - http://hdl.handle.net/10754/597860

UR - http://ieeexplore.ieee.org/document/6474161/

UR - http://www.scopus.com/inward/record.url?scp=84875417910&partnerID=8YFLogxK

U2 - 10.1109/MEMSYS.2013.6474161

DO - 10.1109/MEMSYS.2013.6474161

M3 - Conference contribution

SN - 9781467356558

SP - 1

EP - 4

BT - 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)

PB - Institute of Electrical and Electronics Engineers (IEEE)

ER -

Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device

Abstract

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