Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

Hanan Hamamy, Stylianos E. Antonarakis, Luigi Luca Cavalli-Sforza, Samia Temtamy, Giovanni Romeo, Leo P.Ten Kate, Robin L. Bennett, Alison Shaw, Andre Megarbane, Cornelia Van Duijn, Heli Bathija, Siv Fokstuen, Eric Engel, Joel Zlotogora, Emmanouil Dermitzakis, Armand Bottani, Sophie Dahoun, Michael A. Morris, Steve Arsenault, Mona S. AglanMubasshir Ajaz, Ayad Alkalamchi, Dhekra Alnaqeb, Mohamed K. Alwasiyah, Nawfal Anwer, Rawan Awwad, Melissa Bonnefin, Peter Corry, Lorraine Gwanmesia, Gulshan A. Karbani, Maryam Mostafavi, Tommaso Pippucci, Emmanuelle Ranza-Boscardin, Bruno Reversade, Saghira M. Sharif, Marieke E. Teeuw, Alan H. Bittles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

226 Scopus citations

Abstract

Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies. © 2011 Lippincott Williams &Wilkins.
Original languageEnglish (US)
Title of host publicationGenetics in Medicine
Pages841-847
Number of pages7
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-02-15

ASJC Scopus subject areas

  • Genetics(clinical)

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