Complex macromolecular chimeras

Anastasis Karatzas; Hermis Iatrou; Nikos Hadjichristidis; Kyouichi Inoue; Kenji Sugiyama; Akira Hirao

doi:10.1021/bm800316w

Complex macromolecular chimeras

Anastasis Karatzas, Hermis Iatrou, Nikos Hadjichristidis^*, Kyouichi Inoue, Kenji Sugiyama, Akira Hirao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

By combining two living polymerizations, anionic and ring opening (ROP), the following novel multiblock multicomponent linear and miktoarm star (μ-star) polymer/polypeptide hybrids (macromolecular chimeras) were synthesized: Linear, PBLL-b-PBLG-b-PS-b-PBLG-b-PBLL; 3μ-stars, (PS)₂(PBLG or PBLL), (PS)(PI)(PBLG or PBLL); 4μ-stars, (PS)₂[P(α-MeS)](PBLG or PBLL), (PS)₂(PBLG or PBLL)₂ [PS, polystyrene; PI, polyisoprene; P(α-MeS), poly(α-methylstyrene); PBLG, poly(γ-benzyl-L-glutamate); and PBLL, poly(ε-tert-butyloxycarbonyl-L-lysine)]. The procedure involves (a) the synthesis of end- or in-chain amino-functionalized polymers, by anionic polymerization high vacuum techniques and appropriate linking chemistry and (b) the use of the amino groups for the ROP of α-amino acid carboxyanhydrides (NCAs). Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based mainly on the high vacuum techniques used for the ROP of NCAs, ensuring the avoidance of unwanted polymerization mechanisms and termination reactions.

Original language	English (US)
Pages (from-to)	2072-2080
Number of pages	9
Journal	Biomacromolecules
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/bm800316w
State	Published - Jul 2008
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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@article{50b918ed0be84fe392870c85eaed500f,

title = "Complex macromolecular chimeras",

abstract = "By combining two living polymerizations, anionic and ring opening (ROP), the following novel multiblock multicomponent linear and miktoarm star (μ-star) polymer/polypeptide hybrids (macromolecular chimeras) were synthesized: Linear, PBLL-b-PBLG-b-PS-b-PBLG-b-PBLL; 3μ-stars, (PS)2(PBLG or PBLL), (PS)(PI)(PBLG or PBLL); 4μ-stars, (PS)2[P(α-MeS)](PBLG or PBLL), (PS)2(PBLG or PBLL)2 [PS, polystyrene; PI, polyisoprene; P(α-MeS), poly(α-methylstyrene); PBLG, poly(γ-benzyl-L-glutamate); and PBLL, poly(ε-tert-butyloxycarbonyl-L-lysine)]. The procedure involves (a) the synthesis of end- or in-chain amino-functionalized polymers, by anionic polymerization high vacuum techniques and appropriate linking chemistry and (b) the use of the amino groups for the ROP of α-amino acid carboxyanhydrides (NCAs). Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based mainly on the high vacuum techniques used for the ROP of NCAs, ensuring the avoidance of unwanted polymerization mechanisms and termination reactions.",

author = "Anastasis Karatzas and Hermis Iatrou and Nikos Hadjichristidis and Kyouichi Inoue and Kenji Sugiyama and Akira Hirao",

year = "2008",

month = jul,

doi = "10.1021/bm800316w",

language = "English (US)",

volume = "9",

pages = "2072--2080",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Complex macromolecular chimeras

AU - Karatzas, Anastasis

AU - Iatrou, Hermis

AU - Hadjichristidis, Nikos

AU - Inoue, Kyouichi

AU - Sugiyama, Kenji

AU - Hirao, Akira

PY - 2008/7

Y1 - 2008/7

N2 - By combining two living polymerizations, anionic and ring opening (ROP), the following novel multiblock multicomponent linear and miktoarm star (μ-star) polymer/polypeptide hybrids (macromolecular chimeras) were synthesized: Linear, PBLL-b-PBLG-b-PS-b-PBLG-b-PBLL; 3μ-stars, (PS)2(PBLG or PBLL), (PS)(PI)(PBLG or PBLL); 4μ-stars, (PS)2[P(α-MeS)](PBLG or PBLL), (PS)2(PBLG or PBLL)2 [PS, polystyrene; PI, polyisoprene; P(α-MeS), poly(α-methylstyrene); PBLG, poly(γ-benzyl-L-glutamate); and PBLL, poly(ε-tert-butyloxycarbonyl-L-lysine)]. The procedure involves (a) the synthesis of end- or in-chain amino-functionalized polymers, by anionic polymerization high vacuum techniques and appropriate linking chemistry and (b) the use of the amino groups for the ROP of α-amino acid carboxyanhydrides (NCAs). Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based mainly on the high vacuum techniques used for the ROP of NCAs, ensuring the avoidance of unwanted polymerization mechanisms and termination reactions.

AB - By combining two living polymerizations, anionic and ring opening (ROP), the following novel multiblock multicomponent linear and miktoarm star (μ-star) polymer/polypeptide hybrids (macromolecular chimeras) were synthesized: Linear, PBLL-b-PBLG-b-PS-b-PBLG-b-PBLL; 3μ-stars, (PS)2(PBLG or PBLL), (PS)(PI)(PBLG or PBLL); 4μ-stars, (PS)2[P(α-MeS)](PBLG or PBLL), (PS)2(PBLG or PBLL)2 [PS, polystyrene; PI, polyisoprene; P(α-MeS), poly(α-methylstyrene); PBLG, poly(γ-benzyl-L-glutamate); and PBLL, poly(ε-tert-butyloxycarbonyl-L-lysine)]. The procedure involves (a) the synthesis of end- or in-chain amino-functionalized polymers, by anionic polymerization high vacuum techniques and appropriate linking chemistry and (b) the use of the amino groups for the ROP of α-amino acid carboxyanhydrides (NCAs). Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based mainly on the high vacuum techniques used for the ROP of NCAs, ensuring the avoidance of unwanted polymerization mechanisms and termination reactions.

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U2 - 10.1021/bm800316w

DO - 10.1021/bm800316w

M3 - Article

C2 - 18547108

AN - SCOPUS:48449084666

SN - 1525-7797

VL - 9

SP - 2072

EP - 2080

JO - Biomacromolecules

JF - Biomacromolecules

IS - 7

ER -

Complex macromolecular chimeras

Abstract

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