Comment on recent modeling studies of astrocyte-neuron metabolic interactions

Renaud Jolivet*, Igor Allaman, Luc Pellerin, Pierre J. Magistretti, Bruno Weber

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

69 Scopus citations


Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.

Original languageEnglish (US)
Pages (from-to)1982-1986
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number12
StatePublished - Dec 2010
Externally publishedYes


  • astrocytes
  • glucose
  • lactate
  • mathematical modeling
  • neuronal-glial interaction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Comment on recent modeling studies of astrocyte-neuron metabolic interactions'. Together they form a unique fingerprint.

Cite this