Colorimetric peroxidase mimetic assay for uranyl detection in sea water

Dingyuan Zhang; Zhuo Chen; Haneen Omar; Lin Deng; Niveen M. Khashab

doi:10.1021/am507361x

Colorimetric peroxidase mimetic assay for uranyl detection in sea water

Dingyuan Zhang, Zhuo Chen, Haneen Omar, Lin Deng, Niveen M. Khashab

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68 Scopus citations

Abstract

Uranyl (UO2 2+) is a form of uranium in aqueous solution that represents the greatest risk to human health because of its bioavailability. Different sensing techniques have been used with very sensitive detection limits especially the recently reported uranyl-specific DNAzymes systems. However, to the best of our knowledge, few efficient detection methods have been reported for uranyl sensing in seawater. Herein, gold nanoclusters (AuNCs) are employed in an efficient spectroscopic method to detect uranyl ion (UO2 2+) with a detection limit of 1.86 ÎM. In the absence of UO2 2+, the BSA-stabilized AuNCs (BSA-AuNCs) showed an intrinsic peroxidase-like activity. In the presence of UO2 2+, this activity can be efficiently restrained. The preliminary quenching mechanism and selectivity of UO2 2+ was also investigated and compared with other ions. This design strategy could be useful in understanding the binding affinity of protein-stabilized AuNCs to UO2 2+ and consequently prompt the recycling of UO2 2+ from seawater.

Original language	English (US)
Pages (from-to)	4589-4594
Number of pages	6
Journal	ACS Applied Materials & Interfaces
Volume	7
Issue number	8
DOIs	https://doi.org/10.1021/am507361x
State	Published - Feb 19 2015

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors gratefully acknowledge King Abdullah University of Science and Technology (KAUST) for the support of this work.

ASJC Scopus subject areas

General Materials Science

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10.1021/am507361x

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@article{bb9561cec2714daaaa8a39949fd6ac5b,

title = "Colorimetric peroxidase mimetic assay for uranyl detection in sea water",

abstract = "Uranyl (UO2 2+) is a form of uranium in aqueous solution that represents the greatest risk to human health because of its bioavailability. Different sensing techniques have been used with very sensitive detection limits especially the recently reported uranyl-specific DNAzymes systems. However, to the best of our knowledge, few efficient detection methods have been reported for uranyl sensing in seawater. Herein, gold nanoclusters (AuNCs) are employed in an efficient spectroscopic method to detect uranyl ion (UO2 2+) with a detection limit of 1.86 {\^I}M. In the absence of UO2 2+, the BSA-stabilized AuNCs (BSA-AuNCs) showed an intrinsic peroxidase-like activity. In the presence of UO2 2+, this activity can be efficiently restrained. The preliminary quenching mechanism and selectivity of UO2 2+ was also investigated and compared with other ions. This design strategy could be useful in understanding the binding affinity of protein-stabilized AuNCs to UO2 2+ and consequently prompt the recycling of UO2 2+ from seawater.",

author = "Dingyuan Zhang and Zhuo Chen and Haneen Omar and Lin Deng and Khashab, {Niveen M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors gratefully acknowledge King Abdullah University of Science and Technology (KAUST) for the support of this work.",

year = "2015",

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doi = "10.1021/am507361x",

language = "English (US)",

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T1 - Colorimetric peroxidase mimetic assay for uranyl detection in sea water

AU - Zhang, Dingyuan

AU - Chen, Zhuo

AU - Omar, Haneen

AU - Deng, Lin

AU - Khashab, Niveen M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors gratefully acknowledge King Abdullah University of Science and Technology (KAUST) for the support of this work.

PY - 2015/2/19

Y1 - 2015/2/19

N2 - Uranyl (UO2 2+) is a form of uranium in aqueous solution that represents the greatest risk to human health because of its bioavailability. Different sensing techniques have been used with very sensitive detection limits especially the recently reported uranyl-specific DNAzymes systems. However, to the best of our knowledge, few efficient detection methods have been reported for uranyl sensing in seawater. Herein, gold nanoclusters (AuNCs) are employed in an efficient spectroscopic method to detect uranyl ion (UO2 2+) with a detection limit of 1.86 ÎM. In the absence of UO2 2+, the BSA-stabilized AuNCs (BSA-AuNCs) showed an intrinsic peroxidase-like activity. In the presence of UO2 2+, this activity can be efficiently restrained. The preliminary quenching mechanism and selectivity of UO2 2+ was also investigated and compared with other ions. This design strategy could be useful in understanding the binding affinity of protein-stabilized AuNCs to UO2 2+ and consequently prompt the recycling of UO2 2+ from seawater.

AB - Uranyl (UO2 2+) is a form of uranium in aqueous solution that represents the greatest risk to human health because of its bioavailability. Different sensing techniques have been used with very sensitive detection limits especially the recently reported uranyl-specific DNAzymes systems. However, to the best of our knowledge, few efficient detection methods have been reported for uranyl sensing in seawater. Herein, gold nanoclusters (AuNCs) are employed in an efficient spectroscopic method to detect uranyl ion (UO2 2+) with a detection limit of 1.86 ÎM. In the absence of UO2 2+, the BSA-stabilized AuNCs (BSA-AuNCs) showed an intrinsic peroxidase-like activity. In the presence of UO2 2+, this activity can be efficiently restrained. The preliminary quenching mechanism and selectivity of UO2 2+ was also investigated and compared with other ions. This design strategy could be useful in understanding the binding affinity of protein-stabilized AuNCs to UO2 2+ and consequently prompt the recycling of UO2 2+ from seawater.

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JF - ACS Applied Materials & Interfaces

IS - 8

ER -

Colorimetric peroxidase mimetic assay for uranyl detection in sea water

Abstract

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ASJC Scopus subject areas

UN SDGs

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