Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections

Shahad K. Alsaiari, Mohamed Amen Hammami, Jonas G. Croissant, Haneen Omar, Pradeep Neelakanda, Tahir Yapici, Klaus-Viktor Peinemann, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Healthcare-associated infections (HAIs) are the infections that patients get while receiving medical treatment in a medical facility with bacterial HAIs being the most common. Silver and gold nanoparticles (NPs) have been successfully employed as antibacterial motifs; however, NPs leaching in addition to poor dispersion and overall reproducibility are major hurdles to further product development. In this study, the authors design and fabricate a smart antibacterial mixed-matrix membrane coating comprising colloidal lysozyme-templated gold nanoclusters as nanofillers in poly(ethylene oxide)/poly(butylene terephthalate) amphiphilic polymer matrix. Mesoporous silica nanoparticles-lysozyme functionalized gold nanoclusters disperse homogenously within the polymer matrix with no phase separation and zero NPs leaching. This mixed-matrix coating can successfully sense and inhibit bacterial contamination via a controlled release mechanism that is only triggered by bacteria. The system is coated on a common radiographic dental imaging device (photostimulable phosphor plate) that is prone to oral bacteria contamination. Variation and eventually disappearance of the red fluorescence surface under UV light signals bacterial infection. Kanamycin, an antimicrobial agent, is controllably released to instantly inhibit bacterial growth. Interestingly, the quality of the images obtained with these coated surfaces is the same as uncoated surfaces and thus the safe application of such smart coatings can be expanded to include other medical devices without compromising their utility.
Original languageEnglish (US)
Pages (from-to)1601135
JournalAdvanced healthcare materials
Issue number6
StatePublished - Jan 25 2017

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: S.K.A. and M.A.H. contributed equally to this work. The authors gratefully acknowledge Dr. Abdallah Abdallah from King Abdullah University of Science and Technology (KAUST) for providing E. coli. The authors also thank Dr. Asma'a A. Al-Ekrish from King Saud University and Dr. Alhasan Alsaiari from King Abdulaziz University College of Dentistry for providing and testing the dental imaging plates. The authors declare no competing financial interest.


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