Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines

Huaifeng Li, Abdullah Al Dakhil, Daniel Lupp, Sandeep Suryabhan Gholap, Zhiping Lai, Lan-Chang Liang, Kuo-Wei Huang

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The first example of cobalt-catalyzed selective hydrogenation of nitriles to secondary imines is reported. The results demonstrate the significantly different selectivity compared with the previously reported cobalt catalytic system during the nitrile hydrogenation. A variety of aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines.
Original languageEnglish (US)
Pages (from-to)6430-6435
Number of pages6
JournalOrganic Letters
Issue number20
StatePublished - Oct 2018

Bibliographical note

KAUST Repository Item: Exported on 2021-01-19
Acknowledgements: Financial support was provided by King Abdullah University of Science and Technology (KAUST) and the Ministry of Science and Technology of Taiwan (MOST 106-2113-M-110-003).


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