Coatomer-dependent protein delivery to lipid droplets

Krishnakant G. Soni; Gonzalo A. Mardones; Rachid Sougrat; Elena Smirnova; Catherine L. Jackson; Juan S. Bonifacino

doi:10.1242/jcs.045849

Coatomer-dependent protein delivery to lipid droplets

Krishnakant G. Soni, Gonzalo A. Mardones, Rachid Sougrat, Elena Smirnova, Catherine L. Jackson^*, Juan S. Bonifacino

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators.

Original language	English (US)
Pages (from-to)	1834-1841
Number of pages	8
Journal	Journal of Cell Science
Volume	122
Issue number	11
DOIs	https://doi.org/10.1242/jcs.045849
State	Published - Jun 1 2009
Externally published	Yes

Keywords

ATGL
Lipid droplet
Lipid homeostasis

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1242/jcs.045849

Cite this

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title = "Coatomer-dependent protein delivery to lipid droplets",

abstract = "Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators.",

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T1 - Coatomer-dependent protein delivery to lipid droplets

AU - Soni, Krishnakant G.

AU - Mardones, Gonzalo A.

AU - Sougrat, Rachid

AU - Smirnova, Elena

AU - Jackson, Catherine L.

AU - Bonifacino, Juan S.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators.

AB - Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators.

KW - ATGL

KW - Lipid droplet

KW - Lipid homeostasis

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DO - 10.1242/jcs.045849

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Coatomer-dependent protein delivery to lipid droplets

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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