Metal-enhanced fluorescence (MEF) as a newly recognized technology has been attracting considerable attention and is widely used in fluorescence-based technology. In this paper, we reported a novel distance-dependent MEF and metal-enhanced singlet oxygen generation phenomenon based on silica-coated gold nanorods (AuNRs@SiO2) core-shell structure with tetra-substituted carboxyl aluminum phthalocyanine (AlC4Pc) that serve as both fluorophore and photosensitizer. When the AlC4Pc was linked on the surface of AuNRs@SiO2, the fluorescence intensity and singlet oxygen productivity varied with the thickness difference of silica shell from 2.1 to 28.6 nm. The co-enhancement effect reached the maximum of 7-fold and 2.1-fold, respectively, when the separation distance was 10.6 nm. These unique characteristics make the prepared core-shell nanoparticles promising for MEF-based biological imaging and photodynamics therapy.
Bibliographical noteFunding Information:
This work was financially supported by the National Basic Research Program of China (973 Program) (2013CB933703), the National Natural Science Foundation of China (Nos. 31371012, 81171448, 31428007), and the Medical Science and Technology Innovation Program of Nanjing Military Region (11Z022).
© 2014, Ke et al.; licensee Springer.
- Metal-enhanced fluorescence
- Metal-enhanced singlet oxygen generation
- Silica-coated gold nanorods
- Surface plasmon resonance
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics