With the increased global population, it is more important than ever to expand accessibility to affordable personalized healthcare. In this context, a seamless integration of microfluidic technology for bioanalysis and drug delivery and complementary metal oxide semiconductor (CMOS) technology enabled data-management circuitry is critical. Therefore, here, the fundamentals, integration aspects, and applications of CMOS-enabled microfluidic systems for affordable personalized healthcare systems are presented. Critical components, like sensors, actuators, and their fabrication and packaging, are discussed and reviewed in detail. With the emergence of the Internet-of-Things and the upcoming Internet-of-Everything for a people-process-data-device connected world, now is the time to take CMOS-enabled microfluidics technology to as many people as possible. There is enormous potential for microfluidic technologies in affordable healthcare for everyone, and CMOS technology will play a major role in making that happen.
Bibliographical noteKAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): OSR-2015-Sensors-2707, OSR-2016-KKI-2880
Acknowledgements: The authors deeply appreciate invaluable advice by William E. Ayer, Professor of Engineering Roger Howe of Stanford University. This publication is based upon work supported by the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. Sensor Innovation Initiative OSR-2015-Sensors-2707, KAUST-KFUPM Special Initiative OSR-2016-KKI-2880, and Technology Transfer Office (TTO) under Award No. Proof of Concept GEN-01-4014. The authors also thank Veronica E. Tremblay, Editor, Academic Writing, Office of the Vice President for Research, King Abdullah University of Science and Technology for editorial assistance.