Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis

Ken ichi Ohba; Masashi Mizokami; Tomoyoshi Ohno; Kaoru Suzuki; Etsuro Orito; Yasuo Ina; Johnson Y.N. Lau; Takashi Gojobori

doi:10.1016/0168-1702(95)00007-D

Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis

Ken ichi Ohba, Masashi Mizokami^*, Tomoyoshi Ohno, Kaoru Suzuki, Etsuro Orito, Yasuo Ina, Johnson Y.N. Lau, Takashi Gojobori

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Molecular evolutionary analysis was applied to determine the number of hepatitis C virus (HCV) types and subtyoes based on all the HCV nucleotide sequences available from the DNA data banks (DDBJ, GenBank (NCBI), EMBL) and the literature. There was an excellent concordance among the types and subtypes assigned based on diffeent HCV genomic regions. Only one HCV isolate was assigned to different HCV types based on the 5′ non-coding (NC) and envelope 1 (E1) regions. The 5′ NC region was well conserved and could be used to assign only types and not subtypes. From the sequence data available there were 13 suhtypes based on the core region and 14 subtypes based on the E1 and non-structural proteins 5 (NS5) regions.

Original language	English (US)
Pages (from-to)	201-214
Number of pages	14
Journal	Virus research
Volume	36
Issue number	2-3
DOIs	https://doi.org/10.1016/0168-1702(95)00007-D
State	Published - May 1995
Externally published	Yes

Bibliographical note

Funding Information:
M.M. was supported by grants from the Japanese Ministry of Health and Welfare, Health Science Research grants (Non-A, Non-B Hepatitis Research grants) and Viral Hepatitis Research Foundation of Japan, J.YN.L. was supported in part by the following grants: DSR-RDA-I-15 from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; American Liver Foundation Hans Popper Liver Scholar Award; and Glaxo Institute of Digestive Health Clinical Investigator Award.

Keywords

Genotypes
HCV
Molecular evolutionary analysis
Types

ASJC Scopus subject areas

Virology
Infectious Diseases
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0168-1702(95)00007-D

Cite this

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title = "Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis",

abstract = "Molecular evolutionary analysis was applied to determine the number of hepatitis C virus (HCV) types and subtyoes based on all the HCV nucleotide sequences available from the DNA data banks (DDBJ, GenBank (NCBI), EMBL) and the literature. There was an excellent concordance among the types and subtypes assigned based on diffeent HCV genomic regions. Only one HCV isolate was assigned to different HCV types based on the 5′ non-coding (NC) and envelope 1 (E1) regions. The 5′ NC region was well conserved and could be used to assign only types and not subtypes. From the sequence data available there were 13 suhtypes based on the core region and 14 subtypes based on the E1 and non-structural proteins 5 (NS5) regions.",

keywords = "Genotypes, HCV, Molecular evolutionary analysis, Types",

author = "Ohba, {Ken ichi} and Masashi Mizokami and Tomoyoshi Ohno and Kaoru Suzuki and Etsuro Orito and Yasuo Ina and Lau, {Johnson Y.N.} and Takashi Gojobori",

note = "Funding Information: M.M. was supported by grants from the Japanese Ministry of Health and Welfare, Health Science Research grants (Non-A, Non-B Hepatitis Research grants) and Viral Hepatitis Research Foundation of Japan, J.YN.L. was supported in part by the following grants: DSR-RDA-I-15 from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; American Liver Foundation Hans Popper Liver Scholar Award; and Glaxo Institute of Digestive Health Clinical Investigator Award.",

year = "1995",

month = may,

doi = "10.1016/0168-1702(95)00007-D",

language = "English (US)",

volume = "36",

pages = "201--214",

journal = "Virus research",

issn = "0168-1702",

publisher = "Elsevier B.V.",

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}

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T1 - Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis

AU - Ohba, Ken ichi

AU - Mizokami, Masashi

AU - Ohno, Tomoyoshi

AU - Suzuki, Kaoru

AU - Orito, Etsuro

AU - Ina, Yasuo

AU - Lau, Johnson Y.N.

AU - Gojobori, Takashi

N1 - Funding Information: M.M. was supported by grants from the Japanese Ministry of Health and Welfare, Health Science Research grants (Non-A, Non-B Hepatitis Research grants) and Viral Hepatitis Research Foundation of Japan, J.YN.L. was supported in part by the following grants: DSR-RDA-I-15 from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; American Liver Foundation Hans Popper Liver Scholar Award; and Glaxo Institute of Digestive Health Clinical Investigator Award.

PY - 1995/5

Y1 - 1995/5

N2 - Molecular evolutionary analysis was applied to determine the number of hepatitis C virus (HCV) types and subtyoes based on all the HCV nucleotide sequences available from the DNA data banks (DDBJ, GenBank (NCBI), EMBL) and the literature. There was an excellent concordance among the types and subtypes assigned based on diffeent HCV genomic regions. Only one HCV isolate was assigned to different HCV types based on the 5′ non-coding (NC) and envelope 1 (E1) regions. The 5′ NC region was well conserved and could be used to assign only types and not subtypes. From the sequence data available there were 13 suhtypes based on the core region and 14 subtypes based on the E1 and non-structural proteins 5 (NS5) regions.

AB - Molecular evolutionary analysis was applied to determine the number of hepatitis C virus (HCV) types and subtyoes based on all the HCV nucleotide sequences available from the DNA data banks (DDBJ, GenBank (NCBI), EMBL) and the literature. There was an excellent concordance among the types and subtypes assigned based on diffeent HCV genomic regions. Only one HCV isolate was assigned to different HCV types based on the 5′ non-coding (NC) and envelope 1 (E1) regions. The 5′ NC region was well conserved and could be used to assign only types and not subtypes. From the sequence data available there were 13 suhtypes based on the core region and 14 subtypes based on the E1 and non-structural proteins 5 (NS5) regions.

KW - Genotypes

KW - HCV

KW - Molecular evolutionary analysis

KW - Types

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JF - Virus research

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ER -

Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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