Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis

Ken ichi Ohba, Masashi Mizokami*, Tomoyoshi Ohno, Kaoru Suzuki, Etsuro Orito, Yasuo Ina, Johnson Y.N. Lau, Takashi Gojobori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Molecular evolutionary analysis was applied to determine the number of hepatitis C virus (HCV) types and subtyoes based on all the HCV nucleotide sequences available from the DNA data banks (DDBJ, GenBank (NCBI), EMBL) and the literature. There was an excellent concordance among the types and subtypes assigned based on diffeent HCV genomic regions. Only one HCV isolate was assigned to different HCV types based on the 5′ non-coding (NC) and envelope 1 (E1) regions. The 5′ NC region was well conserved and could be used to assign only types and not subtypes. From the sequence data available there were 13 suhtypes based on the core region and 14 subtypes based on the E1 and non-structural proteins 5 (NS5) regions.

Original languageEnglish (US)
Pages (from-to)201-214
Number of pages14
JournalVirus research
Issue number2-3
StatePublished - May 1995
Externally publishedYes

Bibliographical note

Funding Information:
M.M. was supported by grants from the Japanese Ministry of Health and Welfare, Health Science Research grants (Non-A, Non-B Hepatitis Research grants) and Viral Hepatitis Research Foundation of Japan, J.YN.L. was supported in part by the following grants: DSR-RDA-I-15 from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; American Liver Foundation Hans Popper Liver Scholar Award; and Glaxo Institute of Digestive Health Clinical Investigator Award.


  • Genotypes
  • HCV
  • Molecular evolutionary analysis
  • Types

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research


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