Circadian blueprint of metabolic pathways in the brain

Carolina Magdalen Greco, Paolo Sassone–Corsi

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master or central clock located within the suprachiasmatic nucleus in the hypothalamus governs peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals the presence of additional clocks in the brain and suggests the possibility that circadian circuits may feed back to these from the periphery. Here, we highlight recent advances in the communications between clocks and discuss how they relate to circadian physiology and metabolism.
Original languageEnglish (US)
Pages (from-to)71-82
Number of pages12
JournalNature Reviews Neuroscience
Volume20
Issue number2
DOIs
StatePublished - Dec 17 2018
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2022-06-09
Acknowledgements: The authors thank all members of the Sassone–Corsi laboratory for helpful discussions. Funding for C.M.G. was provided by the National Cancer Institute of the US National Institutes of Health (NIH T32 2T32CA009054-36A1) and by the European Research Council (ERC MSCA-IF-2016 MetEpiClock 749869). Financial support for P.S.-C. was provided by the National Institute of Health, INSERM, a KAUST–UCI partnership and a Novo Nordisk Challenge Grant.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

  • General Neuroscience

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