Abstract
Circadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in ∼24-h cycles. This control is achieved through a complex program of gene expression. In mammals, the molecular clock machinery consists of interconnected transcriptional–translational feedback loops that ultimately ensure the proper oscillation of thousands of genes in a tissue-specific manner. To achieve circadian transcriptional control, chromatin remodelers serve the clock machinery by providing appropriate oscillations to the epigenome. Recent findings have revealed the presence of circadian interactomes, nuclear “hubs” of genome topology where coordinately expressed circadian genes physically interact in a spatial and temporal-specific manner. Thus, a circadian nuclear landscape seems to exist, whose interplay with metabolic pathways and clock regulators translates into specific transcriptional programs. Deciphering the molecular mechanisms that connect the circadian clock machinery with the nuclear landscape will reveal yet unexplored pathways that link cellular metabolism to epigenetic control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6863-6870 |
| Number of pages | 8 |
| Journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
| Volume | 112 |
| Issue number | 22 |
| DOIs | |
| State | Published - 2015 |
| Externally published | Yes |
Bibliographical note
KAUST Repository Item: Exported on 2021-11-01Acknowledgements: We thank all the members of the P.S.-C. laboratory for discussions and insights. Work in the Center for Epigenetics and Metabolism is supported by the National Institutes of Health, Merieux Research Grants, King Abdullah University of Science and Technology, and INSERM. L.A.-A. is supported in part by a European Molecular Biology Organization long-term fellowship.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
ASJC Scopus subject areas
- General