Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

Fei Wang, Wei Zhang, Jieming Zhu, Huaifeng Li, Kuo-Wei Huang, Jinbo Hu

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

A chloride ion-catalyzed generation of difluorocarbene from a relatively non-toxic and inexpensive precursor, Me3SiCF2Cl (1), under mild and neutral conditions leads to an efficient preparation of gem-difluorocyclopropenes and difluorocyclopropanes through [2 + 1] cycloaddition reactions with alkynes and alkenes, respectively. © 2011 The Royal Society of Chemistry.
Original languageEnglish (US)
Pages (from-to)2411-2413
Number of pages3
JournalChem. Commun.
Volume47
Issue number8
DOIs
StatePublished - 2011

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by CAS and NFSC (20772144, 20825209, 20832008) to J.H. and by a KAUST baseline funding to K.-W.H.

ASJC Scopus subject areas

  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Ceramics and Composites
  • General Chemistry
  • Catalysis
  • Electronic, Optical and Magnetic Materials

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